Browsing by Author "Tapia, Juan"

Now showing items 1-4 of 4

    • Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions 

      Samuel, Melanie Ann; Valdez, Gregorio; Tapia, Juan; Lichtman, Jeff; Sanes, Joshua R. (Public Library of Science, 2012)
      As synapses form and mature the synaptic partners produce organizing molecules that regulate each other’s differentiation and ensure precise apposition of pre- and post-synaptic specializations. At the skeletal neuromuscular ...

    • Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise 

      Valdez, G; Tapia, J; Kang, H.; Clemenson, G. D.; Gage, F. H.; Lichtman, Jeff; Sanes, Joshua R. (Proceedings of the National Academy of Sciences, 2010)
      The cellular basis of age-related behavioral decline remains obscure but alterations in synapses are likely candidates. Accordingly, the beneficial effects on neural function of caloric restriction and exercise, which are ...

    • Delayed synapse elimination in mouse levator palpebrae superioris muscle 

      Fox, Michael; Tapia, Juan; Kasthuri, Narayanan; Lichtman, Jeff (Wiley-Blackwell, 2011)
      At birth, synaptic sites in developing rodent muscles are innervated by numerous motor axons. During subsequent weeks, this multiple innervation disappears as one terminal strengthens, and all the others are eliminated. ...

    • The Interscutularis Muscle Connectome 

      Lu, Ju; Tapia, Juan Carlos; White, Olivia L; Lichtman, Jeff (Public Library of Science, 2009)
      The complete connectional map (connectome) of a neural circuit is essential for understanding its structure and function. Such maps have only been obtained in Caenorhabditis elegans. As an attempt at solving mammalian ...