Now showing items 1-5 of 5

    • Biochemical Characterization of Novel Retroviral Integrase Proteins 

      Ballandras-Colas, Allison; Naraharisetty, Hema; Li, Xiang; Serrao, Erik; Engelman, Alan (Public Library of Science, 2013)
      Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication ...
    • Host and viral determinants for MxB restriction of HIV-1 infection 

      Matreyek, Kenneth A; Wang, Weifeng; Serrao, Erik; Singh, Parmit Kumar; Levin, Henry L; Engelman, Alan (BioMed Central, 2014)
      Background: Interferon-induced cellular proteins play important roles in the host response against viral infection. The Mx family of dynamin-like GTPases, which include MxA and MxB, target a wide variety of viruses. Despite ...
    • Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding 

      Serrao, Erik; Krishnan, Lavanya; Shun, Ming-Chieh; Li, Xiang; Cherepanov, Peter; Engelman, Alan; Maertens, Goedele N. (Oxford University Press, 2014)
      Retroviruses favor target-DNA (tDNA) distortion and particular bases at sites of integration, but the mechanism underlying HIV-1 selectivity is unknown. Crystal structures revealed a network of prototype foamy virus (PFV) ...
    • Molecular mechanisms of retroviral integration site selection 

      Kvaratskhelia, Mamuka; Sharma, Amit; Larue, Ross C.; Serrao, Erik; Engelman, Alan (Oxford University Press, 2014)
      Retroviral replication proceeds through an obligate integrated DNA provirus, making retroviral vectors attractive vehicles for human gene-therapy. Though most of the host cell genome is available for integration, the process ...
    • A Unique Viral Reservoir 1 Landscape in HIV-1 Elite Controllers 

      Jiang, Chenyang; Lian, Xiadong; Gao, Ce; Sun, Xiaoming; Einkauf, Kevin B.; Chevalier, Joshua M.; Chen, Samantha; Hua, Stephane; Rhee, Ben; Chang, Kaylee; Blackmer, Jane E.; Osborn, Matthew; Peluso, Michael J.; Hoh, Rebecca; Somsouk, Ma; Milush, Jeffrey; Bertagnolli, Lynn N.; Sweet, Sarah E.; Varriale, Joseph A.; Burbelo, Peter D.; Chun, Tae-Wook; Laird, Gregory M.; Serrao, Erik; Engelman, Alan N.; Carrington, Mary; Siliciano, Robert F.; Siliciano, Janet M.; Deeks, Steven G.; Walker, Bruce D.; Lichterfeld, Mathias; Yu, Xu G.; Yu (Nature Publishing Company, 2020-08-26)