Browsing by Author "Ratai, Eva-Maria"
Now showing items 1-5 of 5
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Anti-α4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection
Campbell, Jennifer H.; Ratai, Eva-Maria; Autissier, Patrick; Nolan, David J.; Tse, Samantha; Miller, Andrew D.; González, R. Gilberto; Salemi, Marco; Burdo, Tricia H.; Williams, Kenneth C. (Public Library of Science, 2014)Four SIV-infected monkeys with high plasma virus and CNS injury were treated with an anti-α4 blocking antibody (natalizumab) once a week for three weeks beginning on 28 days post-infection (late). Infection in the brain ... -
In Vivo Proton Magnetic Resonance Spectroscopy Reveals Region Specific Metabolic Responses to SIV Infection in the Macaque Brain
Pilkenton, Sarah J; Greco, Jane B; Bombardier, Jeffrey P; Turk, Katherine W; He, Julian; Lee, Vallent; Lackner, Andrew A; González, R Gilberto; Ratai, Eva-Maria; Lentz, Margaret R.; Joo, Chan-Gyu; Westmoreland, Susan V.; Halpern, Elkan F. (BioMed Central, 2009)Background: In vivo proton magnetic resonance spectroscopy (1H-MRS) studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. ... -
Minocycline Inhibition of Monocyte Activation Correlates with Neuronal Protection in SIV NeuroAIDS
Campbell, Jennifer H.; Burdo, Tricia H.; Autissier, Patrick; Bombardier, Jeffrey P.; Westmoreland, Susan V.; Soulas, Caroline; Gonzalez, Ramon Gilberto; Ratai, Eva-Maria; Williams, Kenneth C. (Public Library of Science, 2011)Background: Minocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy for HIV-1 associated cognitive disorders. Precise mechanism(s) of minocycline’s functions are not well ... -
A Prospective Longitudinal In Vivo 1H MR Spectroscopy Study of the SIV/macaque Model of NeuroAIDS
Fuller, Robert A; Greco, Jane B; He, Julian; Masliah, Eliezer; Lackner, Andrew A; González, R Gilberto; Westmoreland, Susan V.; Ratai, Eva-Maria; Kim, John P; Lentz, Margaret R.; Sehgal, Prabhat K; Halpern, Elkan F. (BioMed Central, 2004)Background: The neurological complications of HIV infection remain poorly understood. Clinically, in vivo 1H magnetic resonance spectroscopy (MRS) demonstrates brain injury caused by HIV infection even when the MRI is ... -
Proton Magnetic Resonance Spectroscopy Reveals Neuroprotection by Oral Minocycline in a Nonhuman Primate Model of Accelerated NeuroAIDS
Bombardier, Jeffrey P.; Annamalai, Lakshmanan; Burdo, Tricia H.; Fell, Robert; Hakimelahi, Reza; He, Julian; Autissier, Patrick; Masliah, Eliezer; Williams, Kenneth C.; González, R. Gilberto; Ratai, Eva-Maria; Joo, Chan-Gyu; Campbell, Jennifer; Lentz, Margaret R.; Halpern, Elkan F.; Westmoreland, Susan V. (Public Library of Science, 2010)Background: Despite the advent of highly active anti-retroviral therapy (HAART), HIV-associated neurocognitive disorders continue to be a significant problem. In efforts to understand and alleviate neurocognitive deficits ...