Now showing items 1-5 of 5

    • Anti-α4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection 

      Campbell, Jennifer H.; Ratai, Eva-Maria; Autissier, Patrick; Nolan, David J.; Tse, Samantha; Miller, Andrew D.; González, R. Gilberto; Salemi, Marco; Burdo, Tricia H.; Williams, Kenneth C. (Public Library of Science, 2014)
      Four SIV-infected monkeys with high plasma virus and CNS injury were treated with an anti-α4 blocking antibody (natalizumab) once a week for three weeks beginning on 28 days post-infection (late). Infection in the brain ...
    • In Vivo Proton Magnetic Resonance Spectroscopy Reveals Region Specific Metabolic Responses to SIV Infection in the Macaque Brain 

      Pilkenton, Sarah J; Greco, Jane B; Bombardier, Jeffrey P; Turk, Katherine W; He, Julian; Lee, Vallent; Lackner, Andrew A; González, R Gilberto; Ratai, Eva-Maria; Lentz, Margaret R.; Joo, Chan-Gyu; Westmoreland, Susan V.; Halpern, Elkan F. (BioMed Central, 2009)
      Background: In vivo proton magnetic resonance spectroscopy (1H-MRS) studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. ...
    • Minocycline Inhibition of Monocyte Activation Correlates with Neuronal Protection in SIV NeuroAIDS 

      Campbell, Jennifer H.; Burdo, Tricia H.; Autissier, Patrick; Bombardier, Jeffrey P.; Westmoreland, Susan V.; Soulas, Caroline; Gonzalez, Ramon Gilberto; Ratai, Eva-Maria; Williams, Kenneth C. (Public Library of Science, 2011)
      Background: Minocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy for HIV-1 associated cognitive disorders. Precise mechanism(s) of minocycline’s functions are not well ...
    • A Prospective Longitudinal In Vivo 1H MR Spectroscopy Study of the SIV/macaque Model of NeuroAIDS 

      Fuller, Robert A; Greco, Jane B; He, Julian; Masliah, Eliezer; Lackner, Andrew A; González, R Gilberto; Westmoreland, Susan V.; Ratai, Eva-Maria; Kim, John P; Lentz, Margaret R.; Sehgal, Prabhat K; Halpern, Elkan F. (BioMed Central, 2004)
      Background: The neurological complications of HIV infection remain poorly understood. Clinically, in vivo 1H magnetic resonance spectroscopy (MRS) demonstrates brain injury caused by HIV infection even when the MRI is ...
    • Proton Magnetic Resonance Spectroscopy Reveals Neuroprotection by Oral Minocycline in a Nonhuman Primate Model of Accelerated NeuroAIDS 

      Bombardier, Jeffrey P.; Annamalai, Lakshmanan; Burdo, Tricia H.; Fell, Robert; Hakimelahi, Reza; He, Julian; Autissier, Patrick; Masliah, Eliezer; Williams, Kenneth C.; González, R. Gilberto; Ratai, Eva-Maria; Joo, Chan-Gyu; Campbell, Jennifer; Lentz, Margaret R.; Halpern, Elkan F.; Westmoreland, Susan V. (Public Library of Science, 2010)
      Background: Despite the advent of highly active anti-retroviral therapy (HAART), HIV-associated neurocognitive disorders continue to be a significant problem. In efforts to understand and alleviate neurocognitive deficits ...