Now showing items 1-12 of 12

    • Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD 

      Chu, Jen-hwa; Hersh, Craig P; Castaldi, Peter J; Cho, Michael H; Raby, Benjamin A; Laird, Nan; Bowler, Russell; Rennard, Stephen; Loscalzo, Joseph; Quackenbush, John; Silverman, Edwin K (BioMed Central, 2014)
      Background: The investigation of complex disease heterogeneity has been challenging. Here, we introduce a network-based approach, using partial correlations, that analyzes the relationships among multiple disease-related ...
    • The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes 

      Carolan, Brendan J; Hughes, Grant; Morrow, Jarrett; Hersh, Craig P; O’Neal, Wanda K; Rennard, Stephen; Pillai, Sreekumar G; Belloni, Paula; Cockayne, Debra A; Comellas, Alejandro P; Han, Meilan; Zemans, Rachel L; Kechris, Katerina; Bowler, Russell P (BioMed Central, 2014)
      Rationale: Chronic obstructive pulmonary disease (COPD) is a phenotypically heterogeneous disease. In COPD, the presence of emphysema is associated with increased mortality and risk of lung cancer. High resolution computed ...
    • Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study 

      Wells, J. Michael; Estepar, Raul San Jose; McDonald, Merry-Lynn N.; Bhatt, Surya P.; Diaz, Alejandro A.; Bailey, William C.; Jacobson, Francine L.; Dransfield, Mark T.; Washko, George R.; Make, Barry J.; Casaburi, Richard; van Beek, Edwin J. R.; Hoffman, Eric A.; Sciurba, Frank C.; Crapo, James D.; Silverman, Edwin K.; Hersh, Craig P. (BioMed Central, 2016)
      Background: Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little ...
    • Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD 

      Sun, Wei; Kechris, Katerina; Jacobson, Sean; Drummond, M. Bradley; Hawkins, Gregory A.; Yang, Jenny; Chen, Ting-huei; Quibrera, Pedro Miguel; Anderson, Wayne; Barr, R. Graham; Basta, Patricia V.; Bleecker, Eugene R.; Beaty, Terri; Casaburi, Richard; Castaldi, Peter; Cho, Michael H.; Comellas, Alejandro; Crapo, James D.; Criner, Gerard; Demeo, Dawn; Christenson, Stephanie A.; Couper, David J.; Curtis, Jeffrey L.; Doerschuk, Claire M.; Freeman, Christine M.; Gouskova, Natalia A.; Han, MeiLan K.; Hanania, Nicola A.; Hansel, Nadia N.; Hersh, Craig P.; Hoffman, Eric A.; Kaner, Robert J.; Kanner, Richard E.; Kleerup, Eric C.; Lutz, Sharon; Martinez, Fernando J.; Meyers, Deborah A.; Peters, Stephen P.; Regan, Elizabeth A.; Rennard, Stephen I.; Scholand, Mary Beth; Silverman, Edwin K.; Woodruff, Prescott G.; O’Neal, Wanda K.; Bowler, Russell P. (Public Library of Science, 2016)
      Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental ...
    • Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells 

      Zhou, Xiaobo; Qiu, Weiliang; Sathirapongsasuti, J. Fah; Cho, Michael Hyosang; Mancini, John D.; Lao, Taotao; Thibault, Derek M.; Litonjua, Augusto Ampil; Bakke, Per S.; Gulsvik, Amund; Lomas, David A.; Beaty, Terri H.; Hersh, Craig Palmer; Anderson, Christopher David; Geigenmuller, Ute; Raby, Benjamin Alexander; Rennard, Stephen I.; Perrella, Mark A.; Choi, Augustine M.K.; Quackenbush, John; Silverman, Edwin Kepner (Elsevier BV, 2013)
      Hedgehog Interacting Protein (HHIP) was implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS). However, it remains unclear how HHIP contributes to COPD pathogenesis. To identify ...
    • A Genome-wide analysis of the response to inhaled beta2-agonists in Chronic Obstructive Pulmonary Disease 

      Hardin, Megan; Cho, Michael H.; McDonald, Merry-Lynn; Wan, Emily; Lomas, David A.; Coxson, Harvey O.; MacNee, William; Vestbo, Jørgen; Yates, Julie C.; Agusti, Alvar; Calverley, Peter MA; Celli, Bartolome; Crim, Courtney; Rennard, Stephen; Wouters, Emiel; Bakke, Per; Bhatt, Surya P; Kim, Victor; Ramsdell, Joe; Regan, Elizabeth A.; Make, Barry J.; Hokanson, John E.; Crapo, James D.; Beaty, Terri H.; Hersh, Craig P. (2015)
      Short-acting β2-agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have not been ...
    • A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry 

      Lutz, Sharon M.; Cho, Michael H.; Young, Kendra; Hersh, Craig P.; Castaldi, Peter J.; McDonald, Merry-Lynn; Regan, Elizabeth; Mattheisen, Manuel; DeMeo, Dawn L.; Parker, Margaret; Foreman, Marilyn; Make, Barry J.; Jensen, Robert L.; Casaburi, Richard; Lomas, David A.; Bhatt, Surya P.; Bakke, Per; Gulsvik, Amund; Crapo, James D.; Beaty, Terri H.; Laird, Nan M.; Lange, Christoph; Hokanson, John E.; Silverman, Edwin K. (BioMed Central, 2015)
      Background: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ...
    • Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring 

      Lao, Taotao; Glass, Kimberly; Qiu, Weiliang; Polverino, Francesca; Gupta, Kushagra; Morrow, Jarrett; Mancini, John Dominic; Vuong, Linh; Perrella, Mark A; Hersh, Craig P; Owen, Caroline A; Quackenbush, John; Yuan, Guo-Cheng; Silverman, Edwin K; Zhou, Xiaobo (BioMed Central, 2015)
      Background: The HHIP gene, encoding Hedgehog interacting protein, has been implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS), and our subsequent studies identified a ...
    • Opportunities and Challenges in the Genetics of COPD 2010: An International COPD Genetics Conference Report 

      Agusti, Alvar; Anderson, Wayne; Bakke, Per S; Barnes, Kathleen C; Barr, R Graham; Bleecker, Eugene R; Boezen, H Marike; Burkart, Kristin M; Cookson, William OC; Croxton, Thomas; Daley, Denise; Gan, Weiniu; Garcia-Aymerich, Judith; Hall, Ian P; Hansel, Nadia N; Kalsheker, Noor; Kiley, James P; Lambrechts, Diether; Lee, Sang-Do; Lomas, David A; London, Stephanie J; Nishimura, Masaharu; Postma, Dirkje S; Puhan, Milo A; Tesfaigzi, Yohannes; Tobin, Martin D; Vogelmeier, Claus; Wouters, Emiel; Ziegler-Heitbrock, Loems; MacNee, William; Crapo, James D; Vestbo, Jørgen; Silverman, Edwin Kepner; Cho, Michael Hyosang; Celli, Bartolome R; Demeo, Dawn Lisa; Hersh, Craig Palmer; Wilk, Jemma B; Nørdestgaard, Borge G.; Young, Robert P.; O'Donnell, Christopher J.; Kim, Woo Jin; Litonjua, Augusto Ampil (Informa Healthcare, 2011)
    • Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD 

      Hersh, Craig Palmer; Washko, George Richard; Estépar, Raúl San José; Lutz, Sharon; Friedman, Paul J; Han, MeiLan K; Hokanson, John E; Judy, Philip Frank; Lynch, David A; Make, Barry J; Marchetti, Nathaniel; Newell, John D; Sciurba, Frank C; Crapo, James D; Silverman, Edwin Kepner (BioMed Central, 2013)
      Background: Gas trapping quantified on chest CT scans has been proposed as a surrogate for small airway disease in COPD. We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better ...
    • Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort 

      Busch, Robert; Han, MeiLan K.; Bowler, Russell P.; Dransfield, Mark T.; Wells, J Michael; Regan, Elizabeth A.; Hersh, Craig P. (BioMed Central, 2016)
      Background: Despite inhaled medications that decrease exacerbation risk, some COPD patients experience frequent exacerbations. We determined prospective risk factors for exacerbations among subjects in the COPDGene Study ...
    • Xenobiotic Metabolizing Enzyme Gene Polymorphisms Predict Response to Lung Volume Reduction Surgery 

      Hersh, Craig Palmer; Demeo, Dawn Lisa; Reilly, John J.; Silverman, Edwin Kepner (BioMed Central, 2007)
      Background: In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this ...