Now showing items 1-7 of 7

    • The Histone Methyltransferase Set7/9 Promotes Myoblast Differentiation and Myofibril Assembly 

      Tao, Yazhong; Neppl, Ronald; Huang, Zhan-Peng; Chen, Jianfu; Tang, Ru-Hang; Cao, Ru; Zhang, Yi; Jin, Suk-Won; Wang, Da-Zhi (The Rockefeller University Press, 2011)
      The molecular events that modulate chromatin structure during skeletal muscle differentiation are still poorly understood. We report in this paper that expression of the H3-K4 histone methyltransferase Set7 is increased ...
    • MicroRNA-1 and MicroRNA-206 Regulate Skeletal Muscle Satellite Cell Proliferation and Differentiation by Repressing Pax7 

      Chen, Jian-Fu; Tao, Yazhong; Li, Juan; Deng, Zhongliang; Yan, Zhen; Xiao, Xiao; Wang, Da-Zhi (The Rockefeller University Press, 2010)
      Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite cell survival, self-renewal, ...
    • microRNAs in cardiac regeneration and cardiovascular disease 

      Wu, GengZe; Huang, Zhan-Peng; Wang, Da-Zhi (2013)
      microRNAs (miRNAs) are a class of small non-coding RNAs, which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes. miRNAs have been ...
    • Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease 

      Kataoka, Masaharu; Wang, Da-Zhi (MDPI, 2014)
      It has been recognized for decades that proteins, which are encoded by our genome and produced via transcription and translation steps, are building blocks that play vital roles in almost all biological processes. Mutations ...
    • Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases 

      Nie, Mao; Deng, Zhong-Liang; Liu, Jianming; Wang, Da-Zhi (Hindawi Publishing Corporation, 2015)
      A healthy and independent life requires skeletal muscles to maintain optimal function throughout the lifespan, which is in turn dependent on efficient activation of processes that regulate muscle development, homeostasis, ...
    • Transgenic Overexpression of miR-133a in Skeletal Muscle 

      Deng, Zhongliang; Chen, Jian-Fu; Wang, Da-Zhi (BioMed Central, 2011)
      Background: MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of ~22 nucleotides in length. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3' untranslated region (UTR) ...
    • Trbp regulates heart function through miRNA-mediated Sox6 repression 

      Ding, Jian; Chen, Jinghai; Wang, Yanqun; Kataoka, Masaharu; Ma, Lixin; Zhou, Pingzhu; Hu, Xiaoyun; Lin, Zhiqiang; Nie, Mao; Deng, Zhong-Liang; Pu, William T; Wang, Da-Zhi (2015)
      Cardiomyopathy is associated with altered expression of genes encoding contractile proteins. Here we show that Trbp (Tarbp2), an RNA binding protein, is required for normal heart function. Cardiac-specific inactivation of ...