Now showing items 1-12 of 12

    • Autonomous Vascular Networks Synchronize GABA Neuron Migration in the Embryonic Forebrain 

      Won, Chungkil; Lin, Zhicheng; Kumar T, Peeyush; Li, Suyan; Ding, Lai; Elkhal, Abdallah; Szabó, Gábor; Vasudevan, Anju (2013)
      GABA neurons, born in remote germinative zones in the ventral forebrain (telencephalon), migrate tangentially in two spatially distinct streams to adopt their specific positions in the developing cortex. The cell types and ...
    • A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future Prospects 

      Shen, Yan; Huang, Jinsha; Liu, Ling; Xu, Xiaoyun; Han, Chao; Zhang, Guoxin; Jiang, Haiyang; Li, Jie; Lin, Zhicheng; Xiong, Nian; Wang, Tao (Frontiers Media S.A., 2016)
      Parkinson's Disease (PD) is a progressively neurodegenerative disorder, implicitly characterized by a stepwise loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and explicitly marked by ...
    • Effectiveness of Traditional Chinese Medicine as an Adjunct Therapy for Parkinson’s Disease: A Systematic Review and Meta-Analysis 

      Zhang, Guoxin; Xiong, Nian; Zhang, Zhentao; Liu, Ling; Huang, Jinsha; Yang, Jiaolong; Wu, Jing; Lin, Zhicheng; Wang, Tao (Public Library of Science, 2015)
      Background: Idiopathic Parkinson disease (PD) is a common neurodegenerative disease that seriously hinders limb activities and affects patients’ lives. We performed a meta-analysis aiming to systematically review and ...
    • Exosomes and Their Therapeutic Potentials of Stem Cells 

      Han, Chao; Sun, Xuan; Liu, Ling; Jiang, Haiyang; Shen, Yan; Xu, Xiaoyun; Li, Jie; Zhang, Guoxin; Huang, Jinsha; Lin, Zhicheng; Xiong, Nian; Wang, Tao (Hindawi Publishing Corporation, 2016)
      Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are released into the extracellular space when MVBs fuse with the plasma membrane. Numerous studies indicate that exosomes play important ...
    • Genetic Variants in GAPDH Confer Susceptibility to Sporadic Parkinson’s Disease in a Chinese Han Population 

      Liu, Ling; Xiong, Nian; Zhang, Ping; Chen, Chunnuan; Huang, Jinsha; Zhang, Guoxin; Xu, Xiaoyun; Shen, Yan; Lin, Zhicheng; Wang, Tao (Public Library of Science, 2015)
      Background: Accumulating evidence has demonstrated that the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a part of Lewy body inclusions and involves the pathogenesis of Parkinson’s disease (PD). However, it remains ...
    • Glucocerebrosidase L444P Mutation Confers Genetic Risk for Parkinson’s Disease in Central China 

      Wang, Youpei; Zhang, Xiaowei; Chen, Zhenzhen; Yu, Lan; Chen, Chunnuan; Huang, Jinsha; Zhang, Zhentao; Mohmed, Asrah A; Xiong, Nian; Liu, Ling; Xiong, Jing; Lin, Zhicheng; Wang, Tao (BioMed Central, 2012)
      Background: Mutations of the glucocerebrosidase (GBA) gene have reportedly been associated with Parkinson disease (PD) in various ethnic populations such as Singaporean, Japanese, Formosan, Canadian, American, Portuguese, ...
    • Japanese Encephalitis Accompanied by Cerebral Venous Sinus Thrombosis: a Case Report 

      Jia, Min; Xiong, Nian; Huang, Jinsha; Wang, Youpei; Zhang, Xiaowei; Zhang, Zhentao; Cao, Xuebing; Lin, Zhicheng; Wang, Tao (BioMed Central, 2012)
      Background: Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including ...
    • Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement 

      Hou, Lingling; Xiong, Nian; Liu, Ling; Huang, Jinsha; Han, Chao; Zhang, Guoxin; Li, Jie; Xu, Xiaoyun; Lin, Zhicheng; Wang, Tao (BioMed Central, 2015)
      Background: Previous studies have indicated that enhancement of autophagy lysosome pathway may be beneficial for Parkinson’s disease (PD), in which aberrant accumulation of aggregated/misfolded proteins and mitochondrial ...
    • The Role of Autophagy in Parkinson's Disease: Rotenone-Based Modeling 

      Xiong, Nian; Jia, Min; Zhang, Xiaowei; Chen, Zhenzhen; Huang, Jinsha; Zhang, Zhentao; Hou, Lingling; Luo, Zhijian; Ghoorah, Devina; Xiong, Jing; Liu, Ling; Lin, Zhicheng; Wang, Tao (BioMed Central, 2013)
      Background: Autophagy-mediated self-digestion of cytoplasmic inclusions may be protective against neurodegenerative diseases such as Parkinson’s disease (PD). However, excessive autophagic activation evokes autophagic ...
    • Stereotaxical Infusion of Rotenone: A Reliable Rodent Model for Parkinson's Disease 

      Huang, Jinsha; Zhang, Zhentao; Zhang, Zhaowen; Liu, Xingyuan; Jia, Min; Chen, Chunnuan; Cao, Xuebing; Liang, Zhihou; Sun, Shenggang; Xiong, Nian; Xiong, Jing; Wang, Fang; Lin, Zhicheng; Wang, Tao (Public Library of Science, 2009)
      A clinically-related animal model of Parkinson's disease (PD) may enable the elucidation of the etiology of the disease and assist the development of medications. However, none of the current neurotoxin-based models ...
    • Using iPSC‐derived human DA neurons from opioid‐dependent subjects to study dopamine dynamics 

      Sheng, Yang; Filichia, Emily; Shick, Elizabeth; Preston, Kenzie L.; Phillips, Karran A.; Cooperman, Leslie; Lin, Zhicheng; Tesar, Paul; Hoffer, Barry; Luo, Yu (John Wiley and Sons Inc., 2016)
      Abstract Introduction: The dopaminergic (DA) system plays important roles in addiction. However, human DA neurons from drug‐dependent subjects were not available for study until recent development in inducible pluripotent ...
    • Ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects 

      Zhou, Yanhong; Michelhaugh, Sharon K.; Schmidt, Carl J.; Liu, Jun; Bannon, Michael J.; Lin, Zhicheng (Wiley-Blackwell, 2011)
      Altered activity of the human dopamine transporter gene (hDAT) is asssociated with several common and severe brain disorders including cocaine abuse. However, there is little a priori information on whether such alteration ...