Now showing items 1-12 of 12

    • Discovering Shared Cardiovascular Dynamics within a Patient Cohort 

      Nemati, Shamim; Lehman, Li-wei H.; Adams, Ryan Prescott; Malhotra, Atul (Institute of Electrical and Electronics Engineers, 2012)
      Cardiovascular variables such as heart rate (HR) and blood pressure (BP) are robustly regulated by an underlying control system. Time series of HR and BP exhibit distinct dynamical patterns of interaction in response to ...
    • Effects of Aging on Genioglossus Motor Units in Humans 

      Saboisky, Julian P.; Stashuk, Daniel W.; Hamilton-Wright, Andrew; Trinder, John; Nandedkar, Sanjeev; Malhotra, Atul (Public Library of Science, 2014)
      The genioglossus is a major upper airway dilator muscle thought to be important in obstructive sleep apnea pathogenesis. Aging is a risk factor for obstructive sleep apnea although the mechanisms are unclear and the effects ...
    • Increased Sleep Fragmentation Leads to Impaired Off-Line Consolidation of Motor Memories in Humans 

      Djonlagic, Ina; Saboisky, Julian; Carusona, Andrea; Stickgold, Robert A.; Malhotra, Atul (Public Library of Science, 2012)
      A growing literature supports a role for sleep after training in long-term memory consolidation and enhancement. Consequently, interrupted sleep should result in cognitive deficits. Recent evidence from an animal study ...
    • Influencing the Decline of Lung Function in COPD: Use of Pharmacotherapy 

      Gladysheva, Ekaterina S.; Malhotra, Atul; Owens, Robert Llewellyn (Dove Medical Press, 2010)
      Chronic obstructive pulmonary disease (COPD) is a common and deadly disease. One of the hallmarks of COPD is an accelerated decline in lung function, as measured by spirometry. Inflammation, oxidative stress and other ...
    • Is the way to man's heart (and lung) through the abdomen? 

      Owens, Robert Llewellyn; Harris, Robert Scott; Malhotra, Atul (BioMed Central, 2009)
      Intra-abdominal hypertension is increasingly recognized to be both prevalent and clinically important in medical and surgical intensive care units. Intra-abdominal pressure (IAP) can impact organ function throughout the ...
    • Lung Biopsy in ARDS: Is It Worth the Risk? 

      Malhotra, Atul; Patel, Sanjay R (BioMed Central, 2006)
      Progress in the treatment of acute respiratory distress syndrome (ARDS) has been slow, perhaps in part due to the heterogeneity in the biology underlying this syndrome. Open lung biopsy is a feasible approach to define ...
    • Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea 

      Kaczmarek, Elzbieta; Bakker, Jessie P.; Clarke, Douglas N.; Csizmadia, Eva; Kocher, Olivier; Veves, Aristidis; Tecilazich, Francesco; O'Donnell, Christopher P.; Ferran, Christiane; Malhotra, Atul (Public Library of Science, 2013)
      Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ...
    • Sitting and Supine Esophageal Pressures in Overweight and Obese Subjects Authors 

      Owens, Robert L.; Campana, Lisa M.; Hess, Lauren; Eckert, Danny J.; Loring, Stephen H.; Malhotra, Atul (2012)
      Esophageal pressure can be used to approximate pleural pressure and might be clinically useful, particularly in the obese e.g to guide mechanical ventilator settings in critical illness. However, mediastinal artifact (the ...
    • Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea 

      Chung, Frances; Memtsoudis, Stavros G.; Ramachandran, Satya Krishna; Nagappa, Mahesh; Opperer, Mathias; Cozowicz, Crispiana; Patrawala, Sara; Lam, David; Kumar, Anjana; Joshi, Girish P.; Fleetham, John; Ayas, Najib; Collop, Nancy; Doufas, Anthony G.; Eikermann, Matthias; Englesakis, Marina; Gali, Bhargavi; Gay, Peter; Hernandez, Adrian V.; Kaw, Roop; Kezirian, Eric J.; Malhotra, Atul; Mokhlesi, Babak; Parthasarathy, Sairam; Stierer, Tracey; Wappler, Frank; Hillman, David R.; Auckley, Dennis (Lippincott Williams & Wilkins, 2016)
      The purpose of the Society of Anesthesia and Sleep Medicine guideline on preoperative screening and assessment of adult patients with obstructive sleep apnea (OSA) is to present recommendations based on the available ...
    • Tracking progression of patient state of health in critical care using inferred shared dynamics in physiological time series 

      Lehman, Li-Wei; Nemati, Shamim; Adams, Ryan Prescott; Moody, George; Malhotra, Atul; Mark, Rodger G. (Institute of Electrical and Electronics Engineers, 2013)
      Physiologic systems generate complex dynamics in their output signals that reflect the changing state of the underlying control systems. In this work, we used a switching vector autoregressive (switching VAR) framework to ...
    • Transfer Entropy Estimation and Directional Coupling Change Detection in Biomedical Time Series 

      Lee, Joon; Nemati, Shamim; Silva, Ikaro; Edwards, Bradley Allan; Butler, James Preston; Malhotra, Atul (BioMed Central, 2012)
      Background: The detection of change in magnitude of directional coupling between two non-linear time series is a common subject of interest in the biomedical domain, including studies involving the respiratory chemoreflex ...
    • Untreated Sleep-Disordered Breathing: Links to Aging-Related Decline in Sleep-Dependent Memory Consolidation 

      Djonlagic, Ina; Guo, Mengshuang; Matteis, Paul; Carusona, Andrea; Stickgold, Robert; Malhotra, Atul (Public Library of Science, 2014)
      Background: Increasing age is associated with a decline in cognition and motor skills, while at the same time exacerbating one's risk of developing obstructive sleep apnea (OSA). OSA-related cognitive deficits are highly ...