Now showing items 1-12 of 12

    • Acid Suppression Therapy Does Not Predispose to Clostridium difficile Infection: The Case of the Potential Bias 

      Novack, Lena; Kogan, Slava; Gimpelevich, Larisa; Howell, Michael; Borer, Abraham; Kelly, Ciarán P.; Leffler, Daniel A.; Novack, Victor (Public Library of Science, 2014)
      Objective: An adverse effect of acid-suppression medications on the occurrence of Clostridium difficile infection (CDI) has been a common finding of many, but not all studies. We hypothesized that association between ...
    • Active and Secretory IgA-Coated Bacterial Fractions Elucidate Dysbiosis in Clostridium difficile Infection 

      Džunková, Mária; Moya, Andrés; Vázquez-Castellanos, Jorge F.; Artacho, Alejandro; Chen, Xinhua; Kelly, Ciaran; D’Auria, Giuseppe (American Society for Microbiology, 2016)
      ABSTRACT The onset of Clostridium difficile infection (CDI) has been associated with treatment with wide-spectrum antibiotics. Antibiotic treatment alters the activity of gut commensals and may result in modified patterns ...
    • The burden of clostridium difficile infection: estimates of the incidence of CDI from U.S. Administrative databases 

      Olsen, Margaret A.; Young-Xu, Yinong; Stwalley, Dustin; Kelly, Ciarán P.; Gerding, Dale N.; Saeed, Mohammed J.; Mahé, Cedric; Dubberke, Erik R. (BioMed Central, 2016)
      Background: Many administrative data sources are available to study the epidemiology of infectious diseases, including Clostridium difficile infection (CDI), but few publications have compared CDI event rates across databases ...
    • Clostridium difficile outbreaks: Prevention and treatment strategies 

      Martinez, Fernando J; Leffler, Daniel Alexander; Kelly, Ciaran Patrick (Dove Medical Press, 2012)
      The incidence and severity of Clostridium difficile infection (CDI) have increased dramatically over the past decade. Its treatment, however, has largely remained the same with the exception of oral vancomycin use as a ...
    • Identification of Medicare Recipients at Highest Risk for Clostridium difficile Infection in the US by Population Attributable Risk Analysis 

      Dubberke, Erik R.; Olsen, Margaret A.; Stwalley, Dustin; Kelly, Ciarán P.; Gerding, Dale N.; Young-Xu, Yinong; Mahé, Cedric (Public Library of Science, 2016)
      Background: Population attributable risk percent (PAR%) is an epidemiological tool that provides an estimate of the percent reduction in total disease burden if that disease could be entirely eliminated among a subpopulation. ...
    • Identification of Toxemia in Patients with Clostridium difficile Infection 

      Yu, Hua; Chen, Kevin; Wu, Jianguo; Yang, Zhiyong; Shi, Lianfa; Barlow, Lydia L.; Aronoff, David M.; Garey, Kevin W.; Savidge, Tor C.; von Rosenvinge, Erik C.; Kelly, Ciaran P.; Feng, Hanping (Public Library of Science, 2015)
      Toxemia can develop in Clostridium difficile-infected animals, and correlates with severe and fulminant disease outcomes. Circumstantial evidence suggests that toxemia may occur in patients with C. difficile infection ...
    • The Monoclonal Antitoxin Antibodies (Actoxumab–Bezlotoxumab) Treatment Facilitates Normalization of the Gut Microbiota of Mice with Clostridium difficile Infection 

      Džunková, Mária; D'Auria, Giuseppe; Xu, Hua; Huang, Jun; Duan, Yinghua; Moya, Andrés; Kelly, Ciarán P.; Chen, Xinhua (Frontiers Media S.A., 2016)
      Antibiotics have significant and long-lasting impacts on the intestinal microbiota and consequently reduce colonization resistance against Clostridium difficile infection (CDI). Standard therapy using antibiotics is ...
    • A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection 

      Na, Xi; Martin, Alan J.; Sethi, Saurabh; Kyne, Lorraine; Garey, Kevin W.; Flores, Sarah W.; Hu, Mary; Shah, Dhara N.; Shields, Kelsey; Leffler, Daniel A.; Kelly, Ciarán P. (Public Library of Science, 2015)
      Background and Aims Prediction of severe clinical outcomes in Clostridium difficile infection (CDI) is important to inform management decisions for optimum patient care. Currently, treatment recommendations for CDI vary ...
    • Probiotic Yeast Inhibits VEGFR Signaling and Angiogenesis in Intestinal Inflammation 

      Chen, Xinhua; Yang, Guoxun; Song, Joo-Hye; Xu, Huansheng; Li, Dan; Goldsmith, Jeffrey David; Zeng, Huiyan; Parsons-Wingerter, Patricia A.; Reinecker, Hans-Christian; Kelly, Ciaran Patrick (Public Library of Science, 2013)
      Background and Aims Saccharomyces boulardii (Sb) can protect against intestinal injury and tumor formation, but how this probiotic yeast controls protective mucosal host responses is unclear. Angiogenesis is an integral ...
    • A Randomized, Double-Blind Study of Larazotide Acetate to Prevent the Activation of Celiac Disease During Gluten Challenge 

      Leffler, Daniel Alexander; Kelly, Ciaran Patrick; Abdallah, H Z; Colatrella, A M; Harris, L A; Leon, F; Arterburn, L A; Paterson, B M; Lan, Z H; Murray, J A (Nature Publishing Group, 2012)
      OBJECTIVES: In patients with celiac disease, enteropathy is caused by the entry of gluten peptides into the lamina propria of the intestine, in which their immunogenicity is potentiated by tissue transglutaminase (tTG) and ...
    • Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 

      Junker, Yvonne; Zeissig, Sebastian; Kim, Seong-Jun; Barisani, Donatella; Wieser, Herbert; Leffler, Daniel A.; Zevallos, Victor; Libermann, Towia A.; Dillon, Simon; Freitag, Tobias L.; Kelly, Ciaran P.; Schuppan, Detlef (The Rockefeller University Press, 2012)
      Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals (gluten) elicit an adaptive Th1-mediated immune response in ...
    • WSES guidelines for management of Clostridium difficile infection in surgical patients 

      Sartelli, Massimo; Malangoni, Mark A.; Abu-Zidan, Fikri M.; Griffiths, Ewen A.; Di Bella, Stefano; McFarland, Lynne V.; Eltringham, Ian; Shelat, Vishal G.; Velmahos, George C.; Kelly, Ciarán P.; Khanna, Sahil; Abdelsattar, Zaid M.; Alrahmani, Layan; Ansaloni, Luca; Augustin, Goran; Bala, Miklosh; Barbut, Frédéric; Ben-Ishay, Offir; Bhangu, Aneel; Biffl, Walter L.; Brecher, Stephen M.; Camacho-Ortiz, Adrián; Caínzos, Miguel A.; Canterbury, Laura A.; Catena, Fausto; Chan, Shirley; Cherry-Bukowiec, Jill R.; Clanton, Jesse; Coccolini, Federico; Cocuz, Maria Elena; Coimbra, Raul; Cook, Charles H.; Cui, Yunfeng; Czepiel, Jacek; Das, Koray; Demetrashvili, Zaza; Di Carlo, Isidoro; Di Saverio, Salomone; Dumitru, Irina Magdalena; Eckert, Catherine; Eckmann, Christian; Eiland, Edward H.; Enani, Mushira Abdulaziz; Faro, Mario; Ferrada, Paula; Forrester, Joseph Derek; Fraga, Gustavo P.; Frossard, Jean Louis; Galeiras, Rita; Ghnnam, Wagih; Gomes, Carlos Augusto; Gorrepati, Venkata; Ahmed, Mohamed Hassan; Herzog, Torsten; Humphrey, Felicia; Kim, Jae Il; Isik, Arda; Ivatury, Rao; Lee, Yeong Yeh; Juang, Paul; Furuya-Kanamori, Luis; Karamarkovic, Aleksandar; Kim, Peter K; Kluger, Yoram; Ko, Wen Chien; LaBarbera, Francis D.; Lee, Jae Gil; Leppaniemi, Ari; Lohsiriwat, Varut; Marwah, Sanjay; Mazuski, John E.; Metan, Gokhan; Moore, Ernest E.; Moore, Frederick Alan; Nord, Carl Erik; Ordoñez, Carlos A.; Júnior, Gerson Alves Pereira; Petrosillo, Nicola; Portela, Francisco; Puri, Basant K.; Ray, Arnab; Raza, Mansoor; Rems, Miran; Sakakushev, Boris E.; Sganga, Gabriele; Spigaglia, Patrizia; Stewart, David B.; Tattevin, Pierre; Timsit, Jean Francois; To, Kathleen B.; Tranà, Cristian; Uhl, Waldemar; Urbánek, Libor; van Goor, Harry; Vassallo, Angela; Zahar, Jean Ralph; Caproli, Emanuele; Viale, Pierluigi (BioMed Central, 2015)
      In the last two decades there have been dramatic changes in the epidemiology of Clostridium difficile infection (CDI), with increases in incidence and severity of disease in many countries worldwide. The incidence of CDI ...