Browsing by Author "Pizzagalli, Diego"
Now showing items 1-20 of 31
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Acute Stress Reduces Reward Responsiveness: Implications for Depression
Bogdan, Ryan; Pizzagalli, Diego (Elsevier, 2006)Background: Stress, one of the strongest risk factors for depression, has been linked to "anbedonic" behavior and dysfunctional reward-related neural circuitry in preclinical models. Methods: To test if acute stress reduces ... -
Acute Stress Selectively Reduces Reward Sensitivity
Berghorst, Lisa Hinckley; Bogdan, Ryan; Frank, Michael J.; Pizzagalli, Diego A (Frontiers Research Foundation, 2013)Stress may promote the onset of psychopathology by disrupting reward processing. However, the extent to which stress impairs reward processing, rather than incentive processing more generally, is unclear. To evaluate the ... -
Childhood Adversity is Associated with Left Basal Ganglia Dysfunction During Reward Anticipation in Adulthood
Dillon, Daniel G.; Holmes, Avram J.; Birk, Jeffrey L.; Brooks, Nancy; Lyons-Ruth, Karlen; Pizzagalli, Diego (Elsevier, 2009)Background: Childhood adversity increases the risk of psychopathology, but the neurobiological mechanisms underlying this vulnerability are not well-understood. In animal models, early adversity is associated with dysfunction ... -
CNTRICS Final Task Selection: Long-term Memory
Ragland, John D.; Cools, Roshan; Frank, Michael; Pizzagalli, Diego A; Preston, Alison; Ranganath, Charan; Wagner, Anthony D. (Oxford University Press, 2009)Long-term memory (LTM) is a multifactorial construct, composed of different stages of information processing and different cognitive operations that are mediated by distinct neural systems, some of which may be more ... -
The Cognitive Consequences of Emotion Regulation: An ERP Investigation
Deveney, Christen M.; Pizzagalli, Diego (Blackwell Publishers, 2008)Increasing evidence suggests that emotion regulation (ER) strategies modulate encoding of information presented during regulation; however, no studies have assessed the impact of cognitive reappraisal ER strategies on the ... -
Corticostriatal pathways contribute to the natural time course of positive mood
Admon, Roee; Pizzagalli, Diego A. (Nature Publishing Group, 2015)The natural time course of mood includes both acute responses to stimuli and spontaneous fluctuations. To date, neuroimaging studies have focused on either acute affective responses or spontaneous neural fluctuations at ... -
Dissociable Recruitment of Rostral Anterior Cingulate and Inferior Frontal Cortex in Emotional Response Inhibition
Chiu, Pearl H.; Holmes, Avram; Pizzagalli, Diego (Academic Press, 2008)The integrity of decision-making under emotionally evocative circumstances is critical to navigating complex environments, and dysfunctions in these processes may play an important role in the emergence and maintenance of ... -
Dissociation of Neural Regions Associated with Anticipatory Versus Consummatory Phases of Incentive Processing
Bogdan, Ryan; Wald, Lawrence L.; Holmes, Avram; Jahn, Allison L.; Pizzagalli, Diego; Wald, Lawrence; Dillon, Daniel (Blackwell Publishers, 2008)Incentive delay tasks implicate the striatum and medial frontal cortex in reward processing. However, prior studies delivered more rewards than penalties, possibly leading to unwanted differences in signal-to-noise ratio. ... -
Electrophysiological Correlates of Spatial Orienting Towards Angry Faces: A Source Localization Study
Santesso, Diane L.; Meuret, Alicia E.; Hofmann, Stefan G.; Mueller, Erik M.; Ratner, Kyle G.; Roesch, Etienne B.; Pizzagalli, Diego (Pergamon Press, 2008)The goal of this study was to examine behavioral and electrophysiological correlates of involuntary orienting toward rapidly presented angry faces in non-anxious, healthy adults using a dot-probe task in conjunction with ... -
Electrophysiological Evidence of Attentional Biases in Social Anxiety Disorder
Mueller, E. M.; Hofmann, S. G.; Santesso, D. L.; Meuret, A. E.; Bitran, Stella; Pizzagalli, Diego A (Cambridge University Press, 2009)Background: Previous studies investigating attentional biases in social anxiety disorder (SAD) have yielded mixed results. Recent event-related potential (ERP) studies using the dot-probe paradigm in non-anxious participants ... -
Enhanced Negative Feedback Responses in Remitted Depression
Santesso, Diane L.; Steele, Katherine T.; Bogdan, Ryan; Holmes, Avram J.; Deveney, Christen M.; Meites, Tiffany M.; Pizzagalli, Diego (Lippincott Williams & Wilkins, 2008)Major depressive disorder (MDD)is characterized by hypersensitivity to negative feedback that might involve frontocingulate dysfunction. MDD patients exhibit enhanced electrophysiological responses to negative internal ... -
Euthymic Patients with Bipolar Disorder Show Decreased Reward Learning in a Probabilistic Reward Task
Pizzagalli, Diego A; Goetz, Elena; Ostacher, Michael; Iosifescu, Dan V.; Perlis, Roy H. (Elsevier, 2008)Background: Bipolar disorder (BPD) features cycling mood states ranging from depression to mania with intermittent phases of euthymia. Bipolar disorder subjects often show excessive goal-directed and pleasure-seeking ... -
Examining the Relationships between Stress, Reward Processing, and Bipolar Disorder
Berghorst, Lisa Hinckley (2013-03-08)Bipolar disorder (BD) is a prevalent illness associated with severe impairments in functioning and elusive etiological pathways. Although a strong link between negative life stress and the onset of mood episodes in BD has ... -
The Heritability of Hedonic Capacity and Perceived Stress: A Twin Study Evaluation of Candidate Depressive Phenotypes
Bogdan, Ryan; Pizzagalli, Diego (Cambridge University Press, 2009)Background. Anhedonia and stress sensitivity have been identified as promising depressive phenotypes. Research suggests that stress-induced anhedonia is a possible mechanism underlying the association between stress and ... -
Imaging the pathophysiology of major depressive disorder - from localist models to circuit-based analysis
Treadway, Michael T; Pizzagalli, Diego A (BioMed Central, 2014)The neuroimaging literature of Major Depressive Disorder (MDD) has grown substantially over the last several decades, facilitating great advances in the identification of specific brain regions, neurotransmitter systems ... -
Implicit Depression and Hopelessness in Remitted Depressed Individuals
Meites, Tiffany M.; Deveney, Christen M.; Steele, Katherine T.; Holmes, Avram; Pizzagalli, Diego (Elsevier Science, 2008)Cognitive theories of depression posit that automatically activated cognitive schemas, including negative thoughts about the self and the future, predispose individuals to develop depressive disorders. However, prior ... -
Increased Perceived Stress is Associated with Blunted Hedonic Capacity: Potential Implications for Depression Research
Pizzagalli, Diego A; Bogdan, Ryan; Ratner, Kyle G.; Jahn, Allison L. (Elsevier Science, 2007)Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity, in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards ... -
Individual Differences in Reinforcement Learning: Behavioral, Electrophysiological, and Neuroimaging Correlates
Santesso, Diane L.; Dillon, Daniel G.; Birk, Jeffrey L.; Holmes, Avram J.; Goetz, Elena; Bogdan, Ryan; Pizzagalli, Diego (Elsevier, 2008)During reinforcement learning, phasic modulations of activity in midbrain dopamine neurons are conveyed to the dorsal anterior cingulate Cortex (dACC) and basal ganglia (BG) and serve to guide adaptive responding. While ... -
Inhibition of Action, Thought, and Emotion: A Selective Neurobiological Review
Dillon, Daniel; Pizzagalli, Diego (Elsevier, 2007)The neural bases of inhibitory function are reviewed, covering data from paradigms assessing inhibition of motor responses (antisaccade, go/nogo, stop-signal), cognitive sets (e.g., Wisconsin Card Sort Test), and emotion ... -
Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis
Huys, Quentin JM; Pizzagalli, Diego A; Bogdan, Ryan; Dayan, Peter (BioMed Central, 2013)Background: Depression is characterised partly by blunted reactions to reward. However, tasks probing this deficiency have not distinguished insensitivity to reward from insensitivity to the prediction errors for reward ...