Browsing by Author "Lee, Jonathan J."
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Epigenetic Dysregulation in Cutaneous Malignant Melanoma: Advancing Approaches to Diagnosis, Prognosis, and Therapeutic Targeting
Lee, Jonathan J. (2015-05-13)BACKGROUND: Evidence is rapidly accumulating that epigenetic mechanisms, including DNA methylation and demethylation, histone modifications, and non-coding RNAs, may play a central role in the pathobiology of melanoma. ... -
Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction
Wang, Tao; Xu, Chenchen; Zhou, Xiping; Li, Chunjia; Zhang, Hongbing; Lian, Bill Q.; Lee, Jonathan J.; Shen, Jun; Liu, Yuehua; Lian, Christine Guo (MDPI, 2015)Non-bullous congenital ichthyosiform erythroderma (NBCIE) is a hereditary disorder of keratinization caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte ... -
Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma
Lee, Jonathan J.; Cook, Martin; Mihm, Martin C.; Xu, Shuyun; Zhan, Qian; Wang, Thomas J.; Murphy, George F.; Lian, Christine G. (Impact Journals LLC, 2015)Melanomas in the vertical growth phase (VGP) not infrequently demonstrate cellular heterogeneity. One commonly encountered subpopulation displays small cell/nevoid morphology. Although its significance remains unknown, ...