Now showing items 1-6 of 6

    • Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF‐TIMI48 Trial 

      Xu, Haiyan; Ruff, Christian T.; Giugliano, Robert P.; Murphy, Sabina A.; Nordio, Francesco; Patel, Indravadan; Shi, Minggao; Mercuri, Michele; Antman, Elliott M.; Braunwald, Eugene (John Wiley and Sons Inc., 2016)
      Background: We studied the concomitant use of single antiplatelet therapy (SAPT) on the efficacy and safety of the anti‐Xa agent edoxaban in patients with atrial fibrillation (AF). Methods and Results: ENGAGE AF‐TIMI 48 ...
    • Effects of airborne pollutants on mitochondrial DNA Methylation 

      Byun, Hyang-Min; Panni, Tommaso; Motta, Valeria; Hou, Lifang; Nordio, Francesco; Apostoli, Pietro; Bertazzi, Pier Alberto; Baccarelli, Andrea (BioMed Central, 2013)
      Background: Mitochondria have small mitochondrial DNA (mtDNA) molecules independent from the nuclear DNA, a separate epigenetic machinery that generates mtDNA methylation, and are primary sources of oxidative-stress ...
    • Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF–TIMI 48 Trial 

      Kato, Eri Toda; Giugliano, Robert P.; Ruff, Christian T.; Koretsune, Yukihiro; Yamashita, Takeshi; Kiss, Robert Gabor; Nordio, Francesco; Murphy, Sabina A.; Kimura, Tetsuya; Jin, James; Lanz, Hans; Mercuri, Michele; Braunwald, Eugene; Antman, Elliott M. (John Wiley and Sons Inc., 2016)
      Background: Elderly patients with atrial fibrillation are at higher risk of both ischemic and bleeding events compared to younger patients. In a prespecified analysis from the ENGAGE AF‐TIMI 48 trial, we evaluate clinical ...
    • Short Term Effects of Particle Exposure on Hospital Admissions in the Mid-Atlantic States: A Population Estimate 

      Kloog, Itai; Nordio, Francesco; Zanobetti, Antonella; Coull, Brent A.; Koutrakis, Petros; Schwartz, Joel D. (Public Library of Science, 2014)
      Background: Many studies report significant associations between PM2.5 (particulate matter <2.5 micrometers) and hospital admissions. These studies mostly rely on a limited number of monitors which introduces exposure ...
    • Sudden Cardiac Death in Patients With Atrial Fibrillation: Insights From the ENGAGE AF‐TIMI 48 Trial 

      Eisen, Alon; Ruff, Christian T.; Braunwald, Eugene; Nordio, Francesco; Corbalán, Ramón; Dalby, Anthony; Dorobantu, Maria; Mercuri, Michele; Lanz, Hans; Rutman, Howard; Wiviott, Stephen D.; Antman, Elliott M.; Giugliano, Robert P. (John Wiley and Sons Inc., 2016)
      Background: Recent findings suggest that atrial fibrillation is associated with sudden cardiac death (SCD). We examined the incidence, characteristics, and factors associated with SCD in patients with atrial fibrillation. ...
    • Temporal Stability of Epigenetic Markers: Sequence Characteristics and Predictors of Short-Term DNA Methylation Variations 

      Byun, Hyang-Min; Nordio, Francesco; Coull, Brent Andrew; Tarantini, Letizia; Hou, Lifang; Bonzini, Matteo; Apostoli, Pietro; Bertazzi, Pier Alberto; Baccarelli, Andrea (Public Library of Science, 2012)
      Background: DNA methylation is an epigenetic mechanism that has been increasingly investigated in observational human studies, particularly on blood leukocyte DNA. Characterizing the degree and determinants of DNA methylation ...