Now showing items 1-7 of 7

    • Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy 

      Jiang, Yinghua; Fan, Xiang; Yu, Zhanyang; Liao, Zhengbu; Wang, Xiao-Shu; van Leyen, Klaus; Sun, Xiaochuan; Lo, Eng H.; Wang, Xiaoying (Frontiers Media S.A., 2015)
      Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA ...
    • Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain 

      Navaratna, Deepti; Guo, Shu-Zhen; Hayakawa, Kazhuhide; Wang, Xiaoying; Gerhardinger, Chiara; Lo, Eng H. (American Diabetes Association, 2011)
      Objective: Diabetes is an independent risk factor for stroke. However, the underlying mechanism of how diabetes confers that this risk is not fully understood. We hypothesize that secretion of neurotrophic factors by the ...
    • Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice 

      Foerch, Christian; Rosidi, Nathanael L.; Schlunk, Frieder; Lauer, Arne; Cianchetti, Flor A.; Mandeville, Emiri T; Arai, Ken; Yigitkanli, Kazim; Fan, Xiang; Wang, Xiaoying; van Leyen, Klaus J.; Steinmetz, Helmuth; Schaffer, Chris B.; Lo, Eng H. (Public Library of Science, 2013)
      Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral ...
    • Magnetic Resonance Characterization of Ischemic Tissue Metabolism 

      Cheung, Jerry S; Wang, Xiaoying; Sun, Phillip Zhe (Bentham Open, 2011)
      Magnetic resonance imaging (MRI) and spectroscopy (MRS) are versatile diagnostic techniques capable of characterizing the complex stroke pathophysiology, and hold great promise for guiding stroke treatment. Particularly, ...
    • Neuroglobin, a Novel Target for Endogenous Neuroprotection against Stroke and Neurodegenerative Disorders 

      Liu, Ning; Liu, Jianxiang; Yang, Kevin; Yu, Zhanyang; Wang, Xiaoying (Molecular Diversity Preservation International (MDPI), 2012)
      Brain neurons and tissues respond to sublethal injury by activating endogenous protective pathways. Recently, following the failure of a large number of clinical trials for protective strategies against stroke that aim to ...
    • Neuroglobin-overexpression reduces traumatic brain lesion size in mice 

      Zhao, Song; Yu, Zhanyang; Xing, Changhong; Hayakawa, Kazuhide; Whalen, Michael Jerome; Lok, Josephine M.; Lo, Eng H.; Wang, Xiaoying (BioMed Central, 2012)
      Background: Accumulating evidence has demonstrated that over-expression of Neuroglobin (Ngb) is neuroprotective against hypoxic/ischemic brain injuries. In this study we tested the neuroprotective effects of Ngb over-expression ...
    • TNFAIP1 contributes to the neurotoxicity induced by Aβ25–35 in Neuro2a cells 

      Liu, Ning; Yu, Zhanyang; Xun, Yu; Li, Miaomiao; Peng, Xiaoning; Xiao, Ye; Hu, Xiang; Sun, Yi; Yang, Manjun; Gan, Shiquan; Yuan, Shishan; Wang, Xiaoying; Xiang, Shuanglin; Zhang, Jian (BioMed Central, 2016)
      Background: Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein ...