Now showing items 1-8 of 8

    • Discovering cancer immunotherapy targets in vivo 

      Zhou, Penghui; Wucherpfennig, Kai W (Landes Bioscience, 2014)
      A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery ...
    • Mechanism of EBV Inducing Anti-Tumour Immunity and Its Therapeutic Use 

      Choi, Il-Kyu; Wang, Zhe; Ke, Qiang; Hong, Min; Paul, Dereck W.; Fernandes, Stacey M.; Hu, Zhuting; Stevens, Jonathan; Guleria, Indira; Kim, Hye-Jung; Cantor, Harvey; Wucherpfennig, Kai; Brown, Jennifer R.; Ritz, Jerome; Zhang, Baochun (Springer Science and Business Media LLC, 2020-12-23)
      Tumour-associated antigens (TAAs) comprise a large collection of non-mutated cellular antigens recognized by T cells in human and murine cancers. Their potential as immunotherapy targets has been explored for over two ...
    • MFG-E8 Blockade Enhances Tumor Immunity in a Murine Breast Cancer Model 

      Draganov, Dobrin Draganov (2013-03-08)
      Milk fat globule - epidermal growth factor - factor 8 protein (MFG-E8) is an important mediator of the tolerogenic functions of GM-CSF, and a dominant-negative RGE mutant augments the therapeutic potential of irradiated, ...
    • MicroRNAs in Normal and Malignant Lymphocytes 

      Moffett, Howell Franklin (2012-12-12)
      MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that can play important roles in developmental transitions by post-transcriptional regulation of mRNA translation and stability. We profiled miRNA expression in mouse ...
    • Polarized release of TCR-enriched microvesicles at the T cell immunological synapse 

      Choudhuri, Kaushik; Llodrá, Jaime; Roth, Eric W.; Tsai, Jones; Gordo, Susana; Wucherpfennig, Kai W.; Kam, Lance; Stokes, David L.; Dustin, Michael L. (2014)
      The recognition events that mediate adaptive cellular immunity and regulate antibody responses depend on intercellular contacts between T cells and antigen presenting cells (APC)1. T cell signaling is initiated at these ...
    • Self-reactive human CD4 T cell clones form unusual immunological synapses 

      Schubert, David; Gordo, Susana; Sabatino, Joseph J.; Vardhana, Santosh; Gagnon, Etienne; Sethi, Dhruv Kam; Seth, Nilufer P.; Choudhuri, Kaushik; Reijonen, Helena; Nepom, Gerald T.; Evavold, Brian D.; Dustin, Michael L.; Wucherpfennig, Kai (The Rockefeller University Press, 2012)
      Recognition of self–peptide-MHC (pMHC) complexes by CD4 T cells plays an important role in the pathogenesis of many autoimmune diseases. We analyzed formation of immunological synapses (IS) in self-reactive T cell clones ...
    • Subclonal Cooperation Drives Metastasis by Modulating Local and Systemic Immune Microenvironments 

      Cristea, Simona; Kwak, Minsuk; Qin, Yuanbo; Laszewski, Tyler; Luoma, Adrienne; Marusyk, Andriy; Wagle, Nikhil; Fang, Rongxin; Polyak, Kornelia; Janiszewska, Michalina; Tabassum, Doris; Castaño, Zafira; Yamamoto, Kimiyo; Kingston, Natalie; Murphy, Katherine; Shu, Shaokun; Harper, Nicholas; Gil del Alcazar, Carlos; Alečković, Maša; Ekram, Muhammad; Cohen, Ofir; Cohen, Ofir; Wucherpfennig, Kai; Michor, Franziska; McAllister, Sandra (Springer Science and Business Media LLC, 2019-07)
      Most human tumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumours have poor clinical outcomes, yet the underlying mechanism remains ...
    • Target discovery for T cell therapy: next steps to advance Immunotherapies 

      Bot, Adrian; Brewer, Joanna E; Eshhar, Zelig; Frankel, Stanley R; Hickman, Emma; Jungbluth, Achim A; Morgan, Richard; Peretz, Yoav; Radvanyi, Laszlo; Ramos, Carlos A; Robbins, Paul F; Wucherpfennig, Kai W (BioMed Central, 2015)
      Investigators from academia and industry gathered on August 14, 2014, in Boston at the Inaugural ImVacS conference entitled “Target Discovery for T Cell Therapy: Next Step to Advance Immunotherapies”. Novel targets, discovery ...