Browsing by Author "Sancak, Yasemin"

Now showing items 1-4 of 4

    • Architecture of the Mitochondrial Calcium Uniporter 

      Oxenoid, Kirill; Dong, Ying; Cao, Chan; Cui, Tanxing; Sancak, Yasemin; Markhard, Andrew L.; Grabarek, Zenon; Kong, Liangliang; Liu, Zhijun; Ouyang, Bo; Cong, Yao; Mootha, Vamsi K.; Chou, James J. (2016)
      Mitochondria from multiple, eukaryotic clades uptake and buffer large amounts of calcium (Ca2+) via an inner membrane transporter called the uniporter. Early studies demonstrated that this transport requires a mitochondrial ...

    • Engineered ascorbate peroxidase as a genetically-encoded reporter for electron microscopy 

      Martell, Jeffrey D.; Deerinck, Thomas J.; Sancak, Yasemin; Poulos, Thomas L.; Mootha, Vamsi K.; Sosinsky, Gina E.; Ellisman, Mark H.; Ting, Alice Y. (2013)
      Electron microscopy (EM) is the standard method for imaging cellular structures with nanometer resolution, but existing genetic tags are inactive in most cellular compartments1 or require light and are difficult to use2. ...

    • MCU encodes the pore conducting mitochondrial calcium currents 

      Chaudhuri, Dipayan; Sancak, Yasemin; Mootha, Vamsi K; Clapham, David E (eLife Sciences Publications, Ltd, 2013)
      Mitochondrial calcium (Ca2+) import is a well-described phenomenon regulating cell survival and ATP production. Of multiple pathways allowing such entry, the mitochondrial Ca2+ uniporter is a highly Ca2+-selective channel ...

    • MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling 

      Plovanich, Molly Elizabeth; Bogorad, Roman L.; Sancak, Yasemin; Kamer, Kimberli Jean; Strittmatter, Laura Anne; Li, Andrew Amos; Girgis, Hany S.; Kuchimanchi, Satya; De Groot, Jack; Speciner, Lauren; Taneja, Nathan; OShea, Jonathan; Koteliansky, Victor; Mootha, Vamsi Krishna (Public Library of Science, 2013)
      Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a ...