Browsing by Author "Lobanov, Alexei"

Now showing items 1-5 of 5

    • Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes 

      Mariotti, Marco; Ridge, Perry G.; Zhang, Yan; Lobanov, Alexei; Pringle, Thomas H.; Guigo, Roderic; Hatfield, Dolph L.; Gladyshev, Vadim (Public Library of Science, 2012)
      Background: Selenium is an essential trace element in mammals due to its presence in proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein genes, and mouse and rat genomes for 24. ...

    • Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae 

      Kaya, Alaattin; Lobanov, Alexei V; Gladyshev, Vadim N (BlackWell Publishing Ltd, 2014)
      The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected ...

    • Gene expression defines natural changes in mammalian lifespan 

      Fushan, Alexey A; Turanov, Anton A; Lee, Sang-Goo; Kim, Eun Bae; Lobanov, Alexei V; Yim, Sun Hee; Buffenstein, Rochelle; Lee, Sang-Rae; Chang, Kyu-Tae; Rhee, Hwanseok; Kim, Jong-So; Yang, Kap-Seok; Gladyshev, Vadim N (BlackWell Publishing Ltd, 2015)
      Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals ...

    • SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins 

      Mariotti, Marco; Lobanov, Alexei V.; Guigo, Roderic; Gladyshev, Vadim N. (Oxford University Press, 2013)
      Selenoproteins are proteins containing an uncommon amino acid selenocysteine (Sec). Sec is inserted by a specific translational machinery that recognizes a stem-loop structure, the SECIS element, at the 3′ UTR of selenoprotein ...

    • UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins 

      Turanov, Anton A.; Lobanov, Alexei V.; Hatfield, Dolph L.; Gladyshev, Vadim N. (Oxford University Press, 2013)
      It is thought that the SelenoCysteine Insertion Sequence (SECIS) element and UGA codon are sufficient for selenocysteine (Sec) insertion. However, we found that UGA supported Sec insertion only at its natural position or ...