Now showing items 1-5 of 5

    • Blood Epigenetic Age may Predict Cancer Incidence and Mortality 

      Zheng, Yinan; Joyce, Brian T.; Colicino, Elena; Liu, Lei; Zhang, Wei; Dai, Qi; Shrubsole, Martha J.; Kibbe, Warren A.; Gao, Tao; Zhang, Zhou; Jafari, Nadereh; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang (Elsevier, 2016)
      Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...
    • Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake 

      Zhong, Jia; Colicino, Elena; Lin, Xinyi; Mehta, Amar; Kloog, Itai; Zanobetti, Antonella; Byun, Hyang‐Min; Bind, Marie‐Abèle; Cantone, Laura; Prada, Diddier; Tarantini, Letizia; Trevisi, Letizia; Sparrow, David; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A. (Blackwell Publishing Ltd, 2015)
      Background: Short‐term fine particles (PM2.5) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility ...
    • DNA methylation age of blood predicts all-cause mortality in later life 

      Marioni, Riccardo E; Shah, Sonia; McRae, Allan F; Chen, Brian H; Colicino, Elena; Harris, Sarah E; Gibson, Jude; Henders, Anjali K; Redmond, Paul; Cox, Simon R; Pattie, Alison; Corley, Janie; Murphy, Lee; Martin, Nicholas G; Montgomery, Grant W; Feinberg, Andrew P; Fallin, M Daniele; Multhaup, Michael L; Jaffe, Andrew E; Joehanes, Roby; Schwartz, Joel; Just, Allan C; Lunetta, Kathryn L; Murabito, Joanne M; Starr, John M; Horvath, Steve; Baccarelli, Andrea A; Levy, Daniel; Visscher, Peter M; Wray, Naomi R; Deary, Ian J (BioMed Central, 2015)
      Background: DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of ...
    • Effects of Air Pollution and Blood Mitochondrial DNA Methylation on Markers of Heart Rate Variability 

      Byun, Hyang‐Min; Colicino, Elena; Trevisi, Letizia; Fan, Tianteng; Christiani, David C.; Baccarelli, Andrea A. (Wiley-Blackwell, 2016)
      Background: The mitochondrion is the primary target of oxidative stress in response to exogenous environments. Mitochondrial DNA (mtDNA) is independent from nuclear DNA and uses separate epigenetic machinery to regulate ...
    • Mitochondrial haplogroups modify the effect of black carbon on age-related cognitive impairment 

      Colicino, Elena; Power, Melinda C; Cox, David G; Weisskopf, Marc G; Hou, Lifang; Alexeeff, Stacy E; Sanchez-Guerra, Marco; Vokonas, Pantel; Spiro III, Avron; Schwartz, Joel; Baccarelli, Andrea A (BioMed Central, 2014)
      Background: Traffic-related air pollution has been linked with impaired cognition in older adults, possibly due to effects of oxidative stress on the brain. Mitochondria are the main source of cellular oxidation. Haplogroups ...