Now showing items 1-8 of 8

    • Alternative Methods for Characterization of Extracellular Vesicles 

      Balaj, Leonora; Tigges, John; Toxavidis, Vasilis; Ivanov, Alexander R.; Skog, Johan; Momen Heravi, Fatemeh; Alian, Sara; Ericsson, Maria; Distel, Robert; Kuo, Winston Patrick (Frontiers Research Foundation, 2012)
      Extracellular vesicles (ECVs) are nano-sized vesicles released by all cells in vitro as well as in vivo. Their role has been implicated mainly in cell–cell communication, but also in disease biomarkers and more recently ...
    • Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome 

      Moncaster, Juliet A.; Lu, Suqian; Burton, Mark A.; Ghosh, Joy G.; Soscia, Stephanie J.; Mocofanescu, Anca; Kuszak, Jer R.; Pineda, Roberto; Moir, Robert D.; Ericsson, Maria; Folkerth, Rebecca Dunn; Robb, Richard Moore; Clark, John I.; Tanzi, Rudolph Emile; Hunter, David; Goldstein, Lee David (Public Library of Science, 2010)
      Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) ...
    • Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody 

      Mailly, Laurent; Xiao, Fei; Lupberger, Joachim; Wilson, Garrick K.; Aubert, Philippe; Duong, François H. T.; Calabrese, Diego; Leboeuf, Céline; Fofana, Isabel; Thumann, Christine; Bandiera, Simonetta; Lütgehetmann, Marc; Volz, Tassilo; Davis, Christopher; Harris, Helen J.; Mee, Christopher J.; Girardi, Erika; Chane-Woon-Ming, Béatrice; Ericsson, Maria; Fletcher, Nicola; Bartenschlager, Ralf; Pessaux, Patrick; Vercauteren, Koen; Meuleman, Philip; Villa, Pascal; Kaderali, Lars; Pfeffer, Sébastien; Heim, Markus H.; Neunlist, Michel; Zeisel, Mirjam B.; Dandri, Maura; McKeating, Jane A.; Robinet, Eric; Baumert, Thomas F. (2015)
      Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer1. Cell entry of HCV2 and other pathogens3-5 is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins ...
    • Differential Expression of Collagen Type V and XI ?-1 in Human Ascending Thoracic Aortic Aneurysms 

      Toumpoulis, Ioannis K.; Oxford, Julia Thom; Cowan, Douglas Burr; Anagnostopoulos, Constantine E.; Rokkas, Chris K.; Chamogeorgakis, Themistocles P.; Angouras, Dimitrios C.; Shemin, Richard J.; Navab, Mohamad; Ericsson, Maria; Federman, Micheline; Levitsky, Sidney; McCully, James Donald (Elsevier BV, 2009)
      Background The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal ...
    • Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection 

      Cowan, Douglas B.; Yao, Rouan; Akurathi, Vamsidhar; Snay, Erin R.; Thedsanamoorthy, Jerusha K.; Zurakowski, David; Ericsson, Maria; Friehs, Ingeborg; Wu, Yaotang; Levitsky, Sidney; del Nido, Pedro J.; Packard, Alan B.; McCully, James D. (Public Library of Science, 2016)
      We have previously shown that transplantation of autologously derived, respiration-competent mitochondria by direct injection into the heart following transient ischemia and reperfusion enhances cell viability and contractile ...
    • The schizophrenia risk gene product miR-137 alters presynaptic plasticity 

      Siegert, Sandra; Seo, Jinsoo; Kwon, Ester J.; Rudenko, Andrii; Cho, Sukhee; Wang, Wenyuan; Flood, Zachary; Martorell, Anthony J.; Ericsson, Maria; Mungenast, Alison E.; Tsai, Li-Huei (2015)
      Non-coding variants in the human MIR137 gene locus increase schizophrenia risk at a genome-wide significance level. However, the functional consequence of these risk alleles is unknown. Here, we examined induced human ...
    • Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons 

      Ha, Sangdeuk; Baver, Scott; Huo, Lihong; Gata, Adriana; Hairston, Joyce; Huntoon, Nicholas; Li, Wenjing; Zhang, Thompson; Benecchi, Elizabeth J.; Ericsson, Maria; Hentges, Shane T.; Bjørbæk, Christian (Public Library of Science, 2013)
      Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP)/Neuropeptide Y (NPY)/GABA neurons produce anorexigenic and orexigenic neuropeptides ...
    • Structure of a Protozoan Virus from the Human Genitourinary Parasite Trichomonas vaginalis 

      Parent, Kristin N.; Takagi, Yuko; Cardone, Giovanni; Olson, Norman H.; Ericsson, Maria; Yang, May; Lee, Yujin; Asara, John M; Fichorova, Raina Nakova; Baker, Timothy S.; Nibert, Max Lee (American Society of Microbiology, 2013)
      The flagellated protozoan Trichomonas vaginalis is an obligate human genitourinary parasite and the most frequent cause of sexually transmitted disease worldwide. Most clinical isolates of T. vaginalis are persistently ...