Now showing items 1-12 of 12

    • Antileukemic Activity of Nuclear Export Inhibitors that Spare Normal Hematopoietic Cells 

      Etchin, Julia; Sun, Q; Kentsis, Alex; Farmer, A; Zhang, Z C; Sanda, Takaomi; Mansour, M R; Barcelo, C; McCauley, D; Kauffman, M; Shacham, S; Christie, A L; Kung, A L; Rodig, Scott J.; Chook, Y M; Look, A. Thomas (Nature Publishing Group, 2013)
      Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of ...
    • ATM-deficient Thymic Lymphoma is Associated with Aberrant tcrd Rearrangement and Gene Amplification 

      Bassing, Craig H.; Brush, James W.; Patel, Harin; Goff, Peter H.; Gatti, Richard A.; Zha, Shan; Sanda, Takaomi; Murphy, Michael M.; Tepsuporn, Suprawee; Look, A. Thomas; Alt, Frederick W. (The Rockefeller University Press, 2010)
      Ataxia telangiectasia mutated (ATM) deficiency predisposes humans and mice to T lineage lymphomas with recurrent chromosome 14 translocations involving the T cell receptor α/δ (Tcra/d) locus. Such translocations have been ...
    • Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia 

      Kentsis, Alex; Reed, Casie; Rice, Kim L.; Sanda, Takaomi; Rodig, Scott J.; Tholouli, Eleni; Christie, Amanda; Valk, Peter J.M.; Delwel, Ruud; Ngo, Vu; Kutok, Jeffery Lorne; Dahlberg, Suzanne E.; Moreau, Lisa A.; Byers, Richard J.; Christensen, James G.; Woude, George Vande; Licht, Jonathan D.; Kung, Andrew L.; Staudt, Louis M.; Look, A. Thomas (Nature Publishing Group, 2012)
      Although the treatment of acute myeloid leukemia (AML) has improved significantly, more than half of all patients develop disease that is refractory to intensive chemotherapy. Functional genomics approaches offer a means ...
    • Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53 

      Sorrells, Shelly; Carbonneau, Seth; Harrington, Erik; Chen, Aye T.; Hast, Bridgid; Milash, Brett; Major, Michael B.; Stewart, Rodney A.; Jette, Cicely; Pyati, Ujwal Jagdeesh; Zon, Leonard Ira; Look, A. Thomas; Zhou, Yi (Public Library of Science, 2012)
      DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought ...
    • CHK1 Inhibition as a Strategy for Targeting Fanconi Anemia (FA) DNA Repair Pathway Deficient Tumors 

      Chen, Clark C; Kennedy, Richard D; Sidi, Samuel; Look, A. Thomas; D'Andrea, Alan David (BioMed Central, 2009)
      Background: DNA repair deficient tumor cells have been shown to accumulate high levels of DNA damage. Consequently, these cells become hyper-dependent on DNA damage response pathways, including the CHK1-kinase-mediated ...
    • Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays 

      Attiyeh, Edward F.; Moreau, Lisa A.; Fortina, Paolo; Maris, John M.; George, Rani E.; Li, Shuli; Neuberg, Donna S.; Li, Cheng; Fox, Edward Alvin; Meyerson, Matthew Langer; Diller, Lisa Robin; Look, A. Thomas (Public Library of Science, 2007)
      Background: Neuroblastomas are characterized by chromosomal alterations with biological and clinical significance. We analyzed paired blood and primary tumor samples from 22 children with high-risk neuroblastoma for loss ...
    • HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia 

      Akahane, Koshi; Sanda, Takaomi; Mansour, Marc R.; Radimerski, Thomas; DeAngelo, Daniel J.; Weinstock, David M.; Look, A. Thomas (2015)
      We previously found that TYK2 tyrosine kinase signaling through its downstream effector phospho-STAT1 (p-STAT1) acts to upregulate BCL2, which in turn mediates aberrant survival of T-cell acute lymphoblastic leukemia (T-ALL) ...
    • Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish 

      Tang, Qin; Moore, John C.; Ignatius, Myron S.; Tenente, Inês M.; Hayes, Madeline N.; Garcia, Elaine G.; Torres Yordán, Nora; Bourque, Caitlin; He, Shuning; Blackburn, Jessica S.; Look, A. Thomas; Houvras, Yariv; Langenau, David M. (Nature Publishing Group, 2016)
      Cancers contain a wide diversity of cell types that are defined by differentiation states, genetic mutations and altered epigenetic programmes that impart functional diversity to individual cells. Elevated tumour cell ...
    • Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency 

      Blackburn, Jessica S.; Liu, Sali; Raiser, Dave Michael; Martinez, Sarah A.; Feng, Hui; Meeker, Nathan D.; Gentry, Jeffery; Neuberg, Donna S.; Look, A. Thomas; Ramaswamy, Sridhar; Bernards, Andre; Trede, Nikolaus S.; Langenau, David M. (2012)
      NOTCH1 pathway activation contributes to the pathogenesis of over 60% of T-cell acute lymphoblastic leukemia (T-ALL). While Notch is thought to exert the majority of its effects through transcriptional activation of Myc, ...
    • Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia 

      Reynolds, Christine; Roderick, Justine E.; LaBelle, James L.; Bird, Gregory; Mathieu, Ronald; Bodaar, Kimberly; Colon, Diana; Pyati, Ujwal; Stevenson, Kristen E.; Qi, Jun; Harris, Marian; Silverman, Lewis B.; Sallan, Stephen E.; Bradner, James E.; Neuberg, Donna S.; Look, A. Thomas; Walensky, Loren D.; Kelliher, Michelle A.; Gutierrez, Alejandro (2014)
      Treatment resistance in T-cell acute lymphoblastic leukemia (T-ALL) is associated with PTEN deletions and resultant PI3K-AKT pathway activation, as well as MYC overexpression, and these pathways repress mitochondrial ...
    • T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation 

      Feng, Hui; Stachura, David L.; White, Richard; Gutierrez, Alejandro; Zhang, Lu; Sanda, Takaomi; Jette, Cicely A.; Testa, Joseph R.; Neuberg, Donna S.; Langenau, David M.; Kutok, Jeffery Lorne; Zon, Leonard Ira; Traver, David; Fleming, Mark Daniel; Kanki, John P.; Look, A. Thomas (Elsevier BV, 2010)
      The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated ...
    • The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia 

      Mansour, Marc R.; Sanda, Takaomi; Lawton, Lee N.; Li, Xiaoyu; Kreslavsky, Taras; Novina, Carl D.; Brand, Marjorie; Gutierrez, Alejandro; Kelliher, Michelle A.; Jamieson, Catriona H.M.; von Boehmer, Harald; Young, Richard A.; Look, A. Thomas (The Rockefeller University Press, 2013)
      The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of human T cell acute lymphoblastic leukemia (T-ALL) and initiates T-ALL in mouse models. By performing global microRNA (miRNA) expression ...