Browsing by Author "Kaya, Alaattin"
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Diversity of Plant Methionine Sulfoxide Reductases B and Evolution of a Form Specific for Free Methionine Sulfoxide
Le, Dung Tien; Tarrago, Lionel; Watanabe, Yasuko; Kaya, Alaattin; Lee, Byung Cheon; Tran, Uyen; Nishiyama, Rie; Fomenko, Dmitri E.; Gladyshev, Vadim N.; Tran, Lam-Son Phan (Public Library of Science, 2013)Methionine can be reversibly oxidized to methionine sulfoxide (MetO) under physiological conditions. Organisms evolved two distinct methionine sulfoxide reductase families (MSRA & MSRB) to repair oxidized methionine residues. ... -
Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae
Kaya, Alaattin; Lobanov, Alexei V; Gladyshev, Vadim N (BlackWell Publishing Ltd, 2014)The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected ... -
Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response
Labunskyy, Vyacheslav M.; Gerashchenko, Maxim V.; Delaney, Joe R.; Kaya, Alaattin; Kennedy, Brian K.; Kaeberlein, Matt; Gladyshev, Vadim N. (Public Library of Science, 2014)Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, ... -
Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino acid status
Lee, Byung Cheon; Kaya, Alaattin; Ma, Siming; Kim, Gwansu; Gerashchenko, Maxim V.; Yim, Sun Hee; Hu, Zhen; Harshman, Lawrence G.; Gladyshev, Vadim N. (2014)Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in ...