Browsing by Author "Sharma, Arun J."
Now showing items 1-5 of 5
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Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
Marselli, Lorella; Thorne, Jeffrey; Dahiya, Sonika; Sgroi, Dennis Charles; Sharma, Arun J.; Bonner-Weir, Susan; Weir, Gordon Campbell; Marchetti, Piero (Public Library of Science, 2010)Background: Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover. Methodology/Principal Findings: Frozen sections were ... -
Postnatal Expansion of the Pancreatic \(\beta\)-Cell Mass Is Dependent on Survivin
Jiang, Yuying; Nishimura, Wataru; Devor-Henneman, Deborah; Kusewitt, Donna; Wang, Haijuan; Holloway, Michael P.; Dohi, Takehiko; Sabo, Edmond; Altieri, Dario C.; Altura, Rachel A.; Robinson, Michael L.; Sharma, Arun J. (American Diabetes Association, 2008)Objective: Diabetes results from a deficiency of functional \(\beta\)-cells due to both an increase in \(\beta\)-cell death and an inhibition of \(\beta\)-cell replication. The molecular mechanisms responsible for these ... -
Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA
Aguayo-Mazzucato, Cristina; Zavacki, Ann Marie; Marinelarena, Alejandra; Hollister-Lock, Jennifer; El Khattabi, Ilham; Marsili, Alessandro; Weir, Gordon C.; Sharma, Arun; Larsen, P. Reed; Bonner-Weir, Susan (American Diabetes Association, 2013)Neonatal β cells do not secrete glucose-responsive insulin and are considered immature. We previously showed the transcription factor MAFA is key for the functional maturation of β cells, but the physiological regulators ... -
The Uncoupling Protein 1 Gene, UCP1, is Expressed in Mammalian Islet Cells and Associated with Acute Insulin Response to Glucose in African American Families from the IRAS Family Study
Sale, Michèle M; Hsu, Fang-Chi; Palmer, Nicholette D; Gordon, Candace J; Keene, Keith L; Borgerink, Hermina M; Bergman, Richard N; Taylor, Kent D; Saad, Mohammed F; Norris, Jill M; Sharma, Arun J. (BioMed Central, 2007)Background: Variants of uncoupling protein genes UCP1 and UCP2 have been associated with a range of traits. We wished to evaluate contributions of known UCP1 and UCP2 variants to metabolic traits in the Insulin Resistance ... -
β-Cell Growth and Regeneration: Replication is Only Part of the Story
Bonner-Weir, Susan; Weir, Gordon Campbell; Li, Wan-Chun; Ouziel-Yahalom, Limor; Guo, Lili; Sharma, Arun J. (American Diabetes Association, 2010)