Now showing items 1-13 of 13

    • Aberrant islet unfolded protein response in type 2 diabetes 

      Engin, Feyza; Nguyen, Truc; Yermalovich, Alena; Hotamisligil, Gökhan S. (Nature Publishing Group, 2014)
      The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through an adaptive signaling cascade called the unfolded protein response (UPR). Accumulating evidence indicates that the canonical UPR is ...
    • Adipose tissue FABP deficiency promotes metabolic reprogramming and positively impacts healthspan 

      Charles, Khanichi Nona (2014-02-25)
      The adipose tissue lipid chaperones aP2 and mal1, also known as fatty acid binding proteins (FABPs), are significant molecules contributing to metabolic homeostasis, whereby their absence promotes physiological changes ...
    • Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity 

      Bartelt, Alexander; Widenmaier, Scott Bradley; Schlein, Christian; Johann, Kornelia; Goncalves, Renata L.S.; Eguchi, Kosei; Fischer, Alexander W; Parlakgul, Gunes; Snyder, Nicole; Nguyen, Truc B; Bruns, Oliver T; Franke, Daniel; Bawendi, Moungi G; Lynes, Matthew David; Leiria, Luiz O; Tseng, Yu-Hua; Inouye, Karen; Arruda, Ana Paula; Hotamisligil, Gokhan S. (Springer Nature, 2018)
      Objective Brown adipose tissue (BAT) generates heat in response to cold, and low BAT activity has been linked to obesity. However, recent studies were inconclusive as to whether BAT is involved in diet‐induced thermogenesis ...
    • Cellular and Systemic Metabolic Adaptations to Energy Status 

      Calay, Ediz Suha (2014-06-06)
      My thesis work has focused on physiological adaptations to nutrient stress; from genes, environment and hormonal perspective, and how failure of these systems result in common chronic diseases.
    • Chronic enrichment of hepatic ER-mitochondria contact sites leads to calcium dependent mitochondrial dysfunction in obesity 

      Arruda, Ana Paula; Pers, Benedicte Mengel; Parlakgül, Güneş; Güney, Ekin; Inouye, Karen; Hotamisligil, Gökhan S. (2015)
      Proper function of the endoplasmic reticulum (ER) and mitochondria is critical for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states including metabolic diseases. Although ...
    • The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue 

      Lynes, Matthew David; Leiria, Luiz; Lundh, Morten; Bartelt, Alexander; Shamsi, Farnaz; Huang, Tianwen; Takahashi, Hirokazu; Hirshman, Michael F; Schlein, Christian; Lee, Alexandra; Baer, Lisa A; May, Francis J; Gao, Fei; Narain, Niven R; Chen, Emily Y; Kiebish, Michael A; Cypess, Aaron; Blüher, Matthias; Goodyear, Laurie Joy; Hotamisligil, Gokhan S.; Stanford, Kristin I; Tseng, Yu-Hua (Springer Nature, 2017)
      Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders such as obesity, diabetes and ...
    • A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting 

      Syamsunarno, Mas Rizky A. A.; Iso, Tatsuya; Hanaoka, Hirofumi; Yamaguchi, Aiko; Obokata, Masaru; Koitabashi, Norimichi; Goto, Kosaku; Hishiki, Takako; Nagahata, Yoshiko; Matsui, Hiroki; Sano, Motoaki; Kobayashi, Masaki; Kikuchi, Osamu; Sasaki, Tsutomu; Maeda, Kazuhisa; Murakami, Masami; Kitamura, Tadahiro; Suematsu, Makoto; YoshitoTsushima; Endo, Keigo; Hotamisligil, Gökhan S.; Kurabayashi, Masahiko (Public Library of Science, 2013)
      During prolonged fasting, fatty acid (FA) released from adipose tissue is a major energy source for peripheral tissues, including the heart, skeletal muscle and liver. We recently showed that FA binding protein 4 (FABP4) ...
    • A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization 

      Liu, Sihao; Brown, Jonathan D.; Stanya, Kristopher J.; Homan, Edwin; Leidl, Mathias; Inouye, Karen; Bhargava, Prerna; Gangl, Matthew R.; Dai, Lingling; Hatano, Ben; Hotamisligil, Gökhan S.; Saghatelian, Alan; Plutzky, Jorge; Lee, Chih-Hao (2014)
      Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal ...
    • Divergent androgen regulation of unfolded protein response pathways drives prostate cancer 

      Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe; Tesikova, Martina; Nenseth, Hatice Zeynep; Zhao, Sen; Fazli, Ladan; Rennie, Paul; Risberg, Bjørn; Wæhre, Håkon; Danielsen, Håvard; Mills, Ian G; Jin, Yang; Hotamisligil, Gökhan; Saatcioglu, Fahri (BlackWell Publishing Ltd, 2015)
      The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As ...
    • Fatty Acid Binding Protein 4 Deficiency Protects against Oxygen-Induced Retinopathy in Mice 

      Saint-Geniez, Magali; Ghelfi, Elisa; Liang, Xiaoliang; Yu, Chenwei; Spencer, Carrie; Abend, Stephanie; Hotamisligil, Gokhan; Cataltepe, Sule (Public Library of Science, 2014)
      Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide due to increasing survival rates of premature infants. Initial suppression, followed by increased production of the retinal vascular ...
    • Novel role of PKR in inflammasome activation and HMGB1 release 

      Lu, Ben; Nakamura, Takahisa; Inouye, Karen; Li, Jianhua; Tang, Yiting; Lundbäck, Peter; Valdes-Ferrer, Sergio I; Olofsson, Peder S.; Kalb, Thomas; Roth, Jesse; Zou, Yongrui; Erlandsson-Harris, Helena; Yang, Huan; Ting, Jenny P-Y; Wang, Haichao; Andersson, Ulf; Antoine, Daniel J.; Chavan, Sangeeta S.; Hotamisligil, Gökhan S.; Tracey, Kevin J. (2014)
      The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an ...
    • Secretory Mechanisms of aP2: an Adipokine Integrating Adipose Depots with Metabolism 

      Erikci Ertunc, Meric (2014-06-06)
      Adipose Fatty Acid Binding Protein 4 (FABP4) or aP2, plays an important role in several immunometabolic pathologies such as type 2 diabetes, atherosclerosis, fatty liver disease, asthma, and cancer. Long considered to be ...
    • Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins 

      Charles, Khanichi N.; Li, Min-Dian; Engin, Feyza; Arruda, Ana Paula; Inouye, Karen; Hotamisligil, Gokhan S. (Elsevier BV, 2017)
      Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a high-calorie diet impairs metabolism and accelerates aging; conversely, calorie restriction (CR) ...