Now showing items 1-20 of 23

    • Aberrant islet unfolded protein response in type 2 diabetes 

      Engin, Feyza; Nguyen, Truc; Yermalovich, Alena; Hotamisligil, Gökhan S. (Nature Publishing Group, 2014)
      The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through an adaptive signaling cascade called the unfolded protein response (UPR). Accumulating evidence indicates that the canonical UPR is ...
    • Adipocyte/macrophage Fatty Acid Binding Proteins Control Integrated Metabolic Responses in Obesity and Diabetes 

      Maeda, Kazuhisa; Cao, Haiming; Kono, Keita; Gorgun, Cem Z.; Furuhashi, Masato; Uysal, Kadir T.; Cao, Qiong; Atsumi, Genichi; Malone, Harry; Krishnan, Bala; Minokoshi, Yasuhiko; Kahn, Barbara B.; Parker, Rex A.; Hotamisligil, Gokhan (Elsevier BV, 2005-02)
      Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, we developed mice with targeted mutations in two related adipocyte FABPs, ...
    • Adipose tissue FABP deficiency promotes metabolic reprogramming and positively impacts healthspan 

      Charles, Khanichi Nona (2014-02-25)
      The adipose tissue lipid chaperones aP2 and mal1, also known as fatty acid binding proteins (FABPs), are significant molecules contributing to metabolic homeostasis, whereby their absence promotes physiological changes ...
    • Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity 

      Bartelt, Alexander; Widenmaier, Scott Bradley; Schlein, Christian; Johann, Kornelia; Goncalves, Renata L.S.; Eguchi, Kosei; Fischer, Alexander W; Parlakgul, Gunes; Snyder, Nicole; Nguyen, Truc B; Bruns, Oliver T; Franke, Daniel; Bawendi, Moungi G; Lynes, Matthew David; Leiria, Luiz O; Tseng, Yu-Hua; Inouye, Karen; Arruda, Ana Paula; Hotamisligil, Gokhan S. (Springer Nature, 2018)
      Objective Brown adipose tissue (BAT) generates heat in response to cold, and low BAT activity has been linked to obesity. However, recent studies were inconclusive as to whether BAT is involved in diet‐induced thermogenesis ...
    • Cellular and Systemic Metabolic Adaptations to Energy Status 

      Calay, Ediz Suha (2014-06-06)
      My thesis work has focused on physiological adaptations to nutrient stress; from genes, environment and hormonal perspective, and how failure of these systems result in common chronic diseases.
    • Chronic enrichment of hepatic ER-mitochondria contact sites leads to calcium dependent mitochondrial dysfunction in obesity 

      Arruda, Ana Paula; Pers, Benedicte Mengel; Parlakgül, Güneş; Güney, Ekin; Inouye, Karen; Hotamisligil, Gökhan S. (2015)
      Proper function of the endoplasmic reticulum (ER) and mitochondria is critical for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states including metabolic diseases. Although ...
    • The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue 

      Lynes, Matthew David; Leiria, Luiz; Lundh, Morten; Bartelt, Alexander; Shamsi, Farnaz; Huang, Tianwen; Takahashi, Hirokazu; Hirshman, Michael F; Schlein, Christian; Lee, Alexandra; Baer, Lisa A; May, Francis J; Gao, Fei; Narain, Niven R; Chen, Emily Y; Kiebish, Michael A; Cypess, Aaron; Blüher, Matthias; Goodyear, Laurie Joy; Hotamisligil, Gokhan S.; Stanford, Kristin I; Tseng, Yu-Hua (Springer Nature, 2017)
      Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders such as obesity, diabetes and ...
    • Coordinated regulation of protein synthesis and degradation by mTORC1 

      Zhang, Yinan; Nicholatos, Justin William; Dreier, John; Ricoult, Stephane Jean Hermann; Widenmaier, Scott Bradley; Hotamisligil, Gokhan S.; Kwiatkowski, David Joseph; Manning, Brendan D. (Springer Science and Business Media LLC, 2014-07-13)
      Eukaryotic cells coordinately control anabolic and catabolic processes to maintain cell and tissue homeostasis. Mechanistic target of rapamycin complex 1 (mTORC1) promotes nutrient-consuming anabolic processes, such as ...
    • A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting 

      Syamsunarno, Mas Rizky A. A.; Iso, Tatsuya; Hanaoka, Hirofumi; Yamaguchi, Aiko; Obokata, Masaru; Koitabashi, Norimichi; Goto, Kosaku; Hishiki, Takako; Nagahata, Yoshiko; Matsui, Hiroki; Sano, Motoaki; Kobayashi, Masaki; Kikuchi, Osamu; Sasaki, Tsutomu; Maeda, Kazuhisa; Murakami, Masami; Kitamura, Tadahiro; Suematsu, Makoto; YoshitoTsushima; Endo, Keigo; Hotamisligil, Gökhan S.; Kurabayashi, Masahiko (Public Library of Science, 2013)
      During prolonged fasting, fatty acid (FA) released from adipose tissue is a major energy source for peripheral tissues, including the heart, skeletal muscle and liver. We recently showed that FA binding protein 4 (FABP4) ...
    • CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance 

      Chavey, Carine; Lazennec, Gwendal; Lagarrigue, Sylviane; Clapé, Cyrielle; Iankova, Irena; Teyssier, Jacques; Annicotte, Jean-Sébastien; Schmidt, Julien; Mataki, Chikage; Yamamoto, Hiroyasu; Sanches, Rosario; Guma, Anna; Stich, Vladimir; Vitkova, Michaela; Jardin-Watelet, Bénédicte; Renard, Eric; Strieter, Robert; Tuthill, Antoinette; Vidal-Puig, Antonio; Zorzano, Antonio; Langin, Dominique; Fajas, Lluis; Hotamisligil, Gokhan (Elsevier BV, 2009-04)
      We show here high levels of expression and secretion of the chemokine CXC ligand 5 (CXCL5) in the macrophage fraction of white adipose tissue (WAT). Moreover, we find that CXCL5 is dramatically increased in serum of human ...
    • A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization 

      Liu, Sihao; Brown, Jonathan D.; Stanya, Kristopher J.; Homan, Edwin; Leidl, Mathias; Inouye, Karen; Bhargava, Prerna; Gangl, Matthew R.; Dai, Lingling; Hatano, Ben; Hotamisligil, Gökhan S.; Saghatelian, Alan; Plutzky, Jorge; Lee, Chih-Hao (2014)
      Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal ...
    • Divergent androgen regulation of unfolded protein response pathways drives prostate cancer 

      Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe; Tesikova, Martina; Nenseth, Hatice Zeynep; Zhao, Sen; Fazli, Ladan; Rennie, Paul; Risberg, Bjørn; Wæhre, Håkon; Danielsen, Håvard; Mills, Ian G; Jin, Yang; Hotamisligil, Gökhan; Saatcioglu, Fahri (BlackWell Publishing Ltd, 2015)
      The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As ...
    • Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes 

      Hummasti, Sarah; Hotamisligil, Gokhan (Ovid Technologies (Wolters Kluwer Health), 2010-09-03)
      Obesity is a major problem worldwide that increases risk for a wide range of diseases, including diabetes and heart disease. As such, it is increasingly important to understand how excess adiposity can perturb normal ...
    • Fatty Acid Binding Protein 4 Deficiency Protects against Oxygen-Induced Retinopathy in Mice 

      Saint-Geniez, Magali; Ghelfi, Elisa; Liang, Xiaoliang; Yu, Chenwei; Spencer, Carrie; Abend, Stephanie; Hotamisligil, Gokhan; Cataltepe, Sule (Public Library of Science, 2014)
      Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide due to increasing survival rates of premature infants. Initial suppression, followed by increased production of the retinal vascular ...
    • JNK1 Deficiency Does Not Enhance Muscle Glucose Metabolism in Lean Mice 

      Witczak, C.A.; Jessen, N.; Fujii, N.; Seifert, M.M.; Brandauer, J.; Hotamisligil, Gokhan; Hirshman, Michael; Goodyear, Laurie (Elsevier BV, 2006-12)
      Mice deficient in c-jun-NH2-terminal kinase 1 (JNK1) exhibit decreased fasting blood glucose and insulin levels, and protection against obesity-induced insulin resistance, suggesting increased glucose disposal into skeletal ...
    • Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages 

      Zhou, Yi; Yu, Xueqing; Chen, Huimei; Sjöberg, Sara; Roux, Joséphine; Zhang, Lijun; Ivoulsou, Al-Habib; Bensaid, Farid; Liu, Jian; Tordjman, Joan; Clement, Karine; Lee, Chih-Hao; Libby, Peter; Shi, Guo-Ping; Hotamisligil, Gokhan; Liu, Conglin (Elsevier BV, 2015-12)
      Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-inflammatory functions. MCs in the white adipose tissue (WAT) of lean humans ...
    • Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated Genes 

      Babaev, Vladimir R.; Runner, Robert P.; Fan, Daping; Ding, Lei; Zhang, Youmin; Tao, Huan; Erbay, Ebru; Görgün, Cem Z.; Fazio, Sergio; Linton, MacRae F.; Hotamisligil, Gokhan (Ovid Technologies (Wolters Kluwer Health), 2011-06)
    • Novel role of PKR in inflammasome activation and HMGB1 release 

      Lu, Ben; Nakamura, Takahisa; Inouye, Karen; Li, Jianhua; Tang, Yiting; Lundbäck, Peter; Valdes-Ferrer, Sergio I; Olofsson, Peder S.; Kalb, Thomas; Roth, Jesse; Zou, Yongrui; Erlandsson-Harris, Helena; Yang, Huan; Ting, Jenny P-Y; Wang, Haichao; Andersson, Ulf; Antoine, Daniel J.; Chavan, Sangeeta S.; Hotamisligil, Gökhan S.; Tracey, Kevin J. (2014)
      The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an ...
    • Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men 

      Pischon, Tobias; Hotamisligil, Gokhan; Girman, Cynthia; Rifai, Nader; Hu, Frank; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (American Medical Association (AMA), 2004-04-14)
      Context Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart ...