Browsing by Author "Farhi, Samouil"

Now showing items 1-3 of 3

    • All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins 

      Hochbaum, Daniel R.; Zhao, Yongxin; Farhi, Samouil L.; Klapoetke, Nathan; Werley, Christopher A.; Kapoor, Vikrant; Zou, Peng; Kralj, Joel M.; Maclaurin, Dougal; Smedemark-Margulies, Niklas; Saulnier, Jessica L.; Boulting, Gabriella L.; Straub, Christoph; Cho, Yong Ku; Melkonian, Michael; Wong, Gane Ka-Shu; Harrison, D. Jed; Murthy, Venkatesh N.; Sabatini, Bernardo; Boyden, Edward S.; Campbell, Robert E.; Cohen, Adam E. (2014)
      All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, ...

    • Photostick: a method for selective isolation of target cells from culture 

      Chien, Miao-ping; Werley, Christopher A; Farhi, Samouil Leon; Cohen, Adam Ezra (Royal Society of Chemistry (RSC), 2015)
      Sorting of target cells from a heterogeneous pool is technically difficult when the selection criterion is complex, e.g. a dynamic response, a morphological feature, or a combination of multiple parameters. At present, ...

    • Pyramidal Neuron Subtype Diversity Governs Microglia States in the Neocortex 

      Stogsdill, Jeffrey; Kim, Kwanho; Binan, Loïc; Farhi, Samouil; Levin, Joshua; Arlotta, Paola (Springer Science and Business Media LLC, 2022-08-10)
      Microglia are macrophages of the brain parenchyma that exist in multiple transcriptional states and reside within a wide range of neuronal environments. However, it is poorly understood how and where these states are ...