Browsing by Author "Kwon, Douglas"
Now showing items 1-8 of 8
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Altered distribution of mucosal NK cells during HIV infection
Sips, Magdalena; Sciaranghella, Gaia; Diefenbach, Thomas; Dugast, Anne-Sophie; Berger, Christoph T.; Liu, Qingquan; Kwon, Douglas; Ghebremichael, Musie; Estes, Jacob D.; Carrington, Mary; Martin, Jeffrey N.; Deeks, Steven G.; Hunt, Peter W.; Alter, Galit (2013)The human gut mucosa is a major site of HIV infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells play an important role in control of HIV infection but the mechanism(s) ... -
Discovery and characterization of the ligands of NK-cell receptors implicated in human diseases
Garcia Beltran, Wilfredo F. (2016-08-31)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that act as first-line defenders against intracellular pathogens. Their functions are dictated by germline-encoded activating and inhibitory ... -
Efficient Nucleic Acid Extraction and 16S rRNA Gene Sequencing for Bacterial Community Characterization
Anahtar, Melis N.; Bowman, Brittany A.; Kwon, Douglas S. (MyJove Corporation, 2016)There is a growing appreciation for the role of microbial communities as critical modulators of human health and disease. High throughput sequencing technologies have allowed for the rapid and efficient characterization ... -
Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial
Gandhi, Rajesh T.; Kwon, Douglas S.; Macklin, Eric A.; Shopis, Janet R.; McLean, Anna P.; McBrine, Nicole; Flynn, Theresa; Peter, Lauren; Sbrolla, Amy; Kaufmann, Daniel E.; Porichis, Filippos; Walker, Bruce D.; Bhardwaj, Nina; Barouch, Dan H.; Kavanagh, Daniel G. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2015)Background: HIV-1 eradication may require reactivation of latent virus along with stimulation of HIV-1-specific immune responses to clear infected cells. Immunization with autologous dendritic cells (DCs) transfected with ... -
OA031-04. Impairment of HIV-1-specific CD8+ T cell function by soluble epithelial adhesion molecules
Trocha, K; Chevalier, M; Caron, T; Pyo, A; Toth, I; Rodig, SJ; Streeck, Hendrik; Kwon, Douglas; Jolin, Julie Ann; Law, Kayee; Kaufmann, Daniel; Walker, Bruce David; Altfeld, Marcus (BioMed Central, 2009) -
PD-1, IL-10, IFN-γ and IL-12 Form a Network to Regulate HIV-1-Specific CD4 T Cell and Antigen-Presenting Cell Function
Porichis, Filippos; Barblu, Lucie; Kwon, Douglas; Hart, M; Zupkosky, J; Freeman, Gordon James; Kavanagh, Daniel Garrett; Kaufmann, Daniel (BioMed Central, 2012) -
Regulatory T Cells Expanded from HIV-1-Infected Individuals Maintain Phenotype, TCR Repertoire and Suppressive Capacity
Angin, Mathieu; Klarenbeek, Paul L.; King, Melanie; Sharma, Siddhartha M.; Moodley, Eshia S.; Rezai, Ashley; Piechocka-Trocha, Alicja; Toth, Ildiko; Chan, Andrew T.; Goulder, Philip J.; Ndung'u, Thumbi; Kwon, Douglas S.; Addo, Marylyn M. (Public Library of Science, 2014)While modulation of regulatory T cell (Treg) function and adoptive Treg transfer are being explored as therapeutic modalities in the context of autoimmune diseases, transplantation and cancer, their role in HIV-1 pathogenesis ... -
Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection
Vaidya, Sagar A; Streeck, Hendrik; Beckwith, Noor; Ghebremichael, Musie; Pereyra, Florencia; Kwon, Douglas S; Addo, Marylyn M; Rychert, Jenna; Routy, Jean-Pierre; Jessen, Heiko; Kelleher, Anthony D; Hecht, Frederick; Sekaly, Rafick-Pierre; Carrington, Mary; Walker, Bruce D; Allen, Todd M; Rosenberg, Eric S; Altfeld, Marcus (BioMed Central, 2013)Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control ...