Now showing items 1-7 of 7

    • Association of Genetic Loci with Sleep Apnea in European Americans and African-Americans: The Candidate Gene Association Resource (CARe) 

      Patel, Sanjay R.; Goodloe, Robert; De, Gourab; Kowgier, Matthew; Weng, Jia; Buxbaum, Sarah G.; Cade, Brian; Fulop, Tibor; Gharib, Sina A.; Gottlieb, Daniel J.; Hillman, David; Larkin, Emma K.; Lauderdale, Diane S.; Li, Li; Mukherjee, Sutapa; Palmer, Lyle; Zee, Phyllis; Zhu, Xiaofeng; Redline, Susan (Public Library of Science, 2012)
      Although obstructive sleep apnea (OSA) is known to have a strong familial basis, no genetic polymorphisms influencing apnea risk have been identified in cross-cohort analyses. We utilized the National Heart, Lung, and Blood ...
    • The Framingham Heart Study 100K SNP Genome-Wide Association Study Resource: Overview of 17 Phenotype Working Group Reports 

      Cupples, L Adrienne; Arruda, Heather T; Benjamin, Emelia J; D'Agostino, Ralph B; Demissie, Serkalem; DeStefano, Anita L; Dupuis, Josée; Govindaraju, Diddahally R; Heard-Costa, Nancy L; Hwang, Shih-Jen; Kathiresan, Sekar; Laramie, Jason M; Larson, Martin G; Liu, Chun-Yu; Lunetta, Kathryn L; Mailman, Matthew D; Manning, Alisa K; Murabito, Joanne M; O'Connor, George T; Pandey, Mona; Seshadri, Sudha; Vasan, Ramachandran S; Wilk, Jemma B; Wolf, Philip A; Yang, Qiong; Atwood, Larry D; Falls, Kathleen M; Fox, Caroline; Gottlieb, Daniel J; Guo, Chao-yu; Kiel, Douglas P.; Levy, Daniel; Meigs, James Benjamin; Newton-Cheh, Christopher Holmes; O'Donnell, Christopher Joseph; Wang, Zhen (BioMed Central, 2007)
      Background: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...
    • Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits 

      Dashti, Hassan S.; Follis, Jack L.; Smith, Caren E.; Tanaka, Toshiko; Garaulet, Marta; Gottlieb, Daniel J.; Hruby, Adela; Jacques, Paul F.; Kiefte-de Jong, Jessica C.; Lamon-Fava, Stefania; Scheer, Frank A.J.L.; Bartz, Traci M.; Kovanen, Leena; Wojczynski, Mary K.; Frazier-Wood, Alexis C.; Ahluwalia, Tarunveer S.; Perälä, Mia-Maria; Jonsson, Anna; Muka, Taulant; Kalafati, Ioanna P.; Mikkilä, Vera; Ordovás, José M. (American Diabetes Association, 2015)
      OBJECTIVE Common circadian-related gene variants associate with increased risk for metabolic alterations including type 2 diabetes. However, little is known about whether diet and sleep could modify associations between ...
    • A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study 

      Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Borecki, Ingrid B.; O'Connor, George T.; McCarthy, Mark I.; Wilk, Jemma B; Chen, Ting-Hsu; Gottlieb, Daniel J; Myers, Richard Hepworth; Silverman, Edwin Kepner; Weiss, Scott Tillman (Public Library of Science, 2009)
      The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...
    • Lack of impact of mild obstructive sleep apnea on sleepiness, mood and quality of life 

      Quan, Stuart Fun; Budhiraja, Rohit; Batool-Anwar, Salma; Gottlieb, Daniel J; Eichling, Phillip; Patel, Sanjay R; Shen, Wei; Walsh, James; Kushida, Clete (Southwest Journal of Pulmonary and Critical Care, 2014)
      Background and Objectives: Obstructive sleep apnea (OSA) is associated with sleepiness, depression and reduced quality of life. However, it is unclear whether mild OSA has these negative impacts. Using data from the Apnea ...
    • Predictors of sleepiness in obstructive sleep apnoea at baseline and after 6 months of continuous positive airway pressure therapy 

      Budhiraja, Rohit; Kushida, Clete A.; Nichols, Deborah A.; Walsh, James K.; Simon, Richard D.; Gottlieb, Daniel J; Quan, Stuart Fun (European Respiratory Society (ERS), 2017)
      We evaluated factors associated with subjective and objective sleepiness at baseline and after 6 months of continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnoea (OSA).We analysed data ...
    • Predictors of sleepiness in obstructive sleep apnoea at baseline and after 6 months of continuous positive airway pressure therapy 

      Budhiraja, Rohit; Kushida, Clete A.; Nichols, Deborah A.; Walsh, James K.; Simon, Richard D.; Gottlieb, Daniel J; Quan, Stuart Fun (European Respiratory Society (ERS), 2017)