Now showing items 1-5 of 5

    • Association of PCSK1 rs6234 with Obesity and Related Traits in a Chinese Han Population 

      Li, Huaixing; Loos, Ruth J. F.; Wu, Hongyu; Yu, Zhijie; Lin, Xu; Zhang, Cuilin; Qi, Qibin; Liu, Chen; Hu, Frank B. (Public Library of Science, 2010)
      Background: Common variants in PCSK1 have been reported to be associated with obesity in populations of European origin. We aimed to replicate this association in Chinese. Methodology/Principal Findings: Two PCSK1 variants ...
    • CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials 

      Qi, Qibin; Durst, Ronen; Schwarzfuchs, Dan; Leitersdorf, Eran; Shpitzen, Shoshi; Li, Yanping; Wu, Hongyu; Champagne, Catherine M.; Hu, Frank B.; Stampfer, Meir; Bray, George A.; Sacks, Frank Martin; Shai, Iris; Qi, Lu (American Society for Biochemistry & Molecular Biology (ASBMB), 2014)
      Little is known about whether cholesteryl ester transfer protein (CETP) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between ...
    • Genetic Predisposition to Dyslipidemia and Type 2 Diabetes Risk in Two Prospective Cohorts 

      Qi, Qibin; Liang, Liming; Doria, Alessandro; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2012)
      Dyslipidemia has been associated with type 2 diabetes, but it remains unclear whether dyslipidemia plays a causal role in type 2 diabetes. We aimed to examine the association between the genetic predisposition to dyslipdemia ...
    • Identification of New Genetic Risk Variants for Type 2 Diabetes 

      Shu, Xiao Ou; Long, Jirong; Cai, Qiuyin; Xiang, Yong-Bing; Tai, E. Shyong; Li, Xiangyang; Lin, Xu; Chow, Wong-Ho; Go, Min Jin; Seielstad, Mark; Li, Huaixing; Yu, Kai; Wen, Wanqing; Shi, Jiajun; Han, Bok-Ghee; Sim, Xue Ling; Liu, Liegang; Kim, Hyung-Lae; Ng, Daniel P. K.; Lee, Jong-Young; Gao, Yu-Tang; Visscher, Peter M.; Qi, Lu; Cho, Yoon-Jae; Bao, Wei; Cornelis, Marilyn; Qi, Qibin; Kim, Young Jin; Li, Chun; Zheng, Wei; Hu, Frank B. (Public Library of Science, 2010)
      Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, ...
    • Vitamin D metabolism-related genetic variants, dietary protein intake and improvement of insulin resistance in a 2 year weight-loss trial: POUNDS Lost 

      Qi, Qibin; Zheng, Yan; Huang, Tao; Rood, Jennifer Evelyn; Bray, George A.; Sacks, Frank Martin; Qi, Lu (Springer Nature, 2015)
      AIMS/HYPOTHESIS: Vitamin D and related genetic variants are associated with obesity and insulin resistance. We aimed to examine whether vitamin D metabolism-related variants affect changes in body weight and insulin ...