Browsing by Author "Perry, George"

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    • Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc 

      Cuajungco, Math P.; Goldstein, Lee E.; Nunomura, Akihiko; Smith, Mark A.; Lim, James T.; Atwood, Craig S.; Huang, Xudong; Farrag, Yasser W.; Perry, George; Bush, Ashley I. (American Society for Biochemistry & Molecular Biology (ASBMB), 2000-05-08)
      Abeta binds Zn(2+), Cu(2+), and Fe(3+) in vitro, and these metals are markedly elevated in the neocortex and especially enriched in amyloid plaque deposits of individuals with Alzheimer's disease (AD). Zn(2+) precipitates ...