Now showing items 1-7 of 7

    • Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis 

      Tanabe, Kenneth Kenji; Lemoine, Antoinette; Finkelstein, Dianne Madelyn; Kawasaki, Hiroshi; Fujii, Tsutomu; Chung, Raymond Taeyong; Lauwers, Gregory Y.; Kulu, Yakup; Muzikansky, Alona; Kuruppu, Darshini; Lanuti, Michael; Goodwin, Jonathan M.; Azoulay, Daniel; Fuchs, Bryan C. (American Medical Association (AMA), 2008)
      Context: Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. Objective: To assess the ...
    • A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients 

      Suenaga, Masaya; Yamada, Suguru; Fujii, Tsutomu; Fuchs, Bryan C; Okumura, Norio; Kanda, Mitsuro; Kobayashi, Daisuke; Tanaka, Chie; Nakayama, Goro; Sugimoto, Hiroyuki; Koike, Masahiko; Nomoto, Shuji; Fujiwara, Michitaka; Takeda, Shin; Hayashi, Kazuhiko; Tanabe, Kenneth K; Goto, Hidemi; Kodera, Yasuhiro (Dove Medical Press, 2013)
      Background: A single nucleotide polymorphism (SNP) in the epidermal growth factor (EGF) gene (rs4444903) has been associated with increased risk of cancer, including hepatocellular carcinoma (HCC). The aim of this study ...
    • Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis 

      King, Lindsay Y.; Johnson, Kara B.; Zheng, Hui; Wei, Lan; Gudewicz, Thomas; Hoshida, Yujin; Corey, Kathleen E.; Ajayi, Tokunbo; Ufere, Nneka; Baumert, Thomas F.; Chan, Andrew T.; Tanabe, Kenneth K.; Fuchs, Bryan C.; Chung, Raymond T. (Public Library of Science, 2014)
      Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene ...
    • Molecular MR Imaging of Liver Fibrosis: A Feasibility Study Using Rat and Mouse Models 

      Polasek, Miloslav; Fuchs, Bryan C.; Uppal, Ritika; Schühle, Daniel T.; Alford, Jamu K.; Loving, Galen S.; Yamada, Suguru; Wei, Lan; Lauwers, Gregory Y.; Guimaraes, Alexander Savio Ramos; Tanabe, Kenneth Kenji; Caravan, Peter D. (Elsevier BV, 2012)
      Background & Aims: Liver biopsy, the current clinical gold standard for fibrosis assessment, is invasive and has sampling errors, and is not optimal for screening, monitoring, or clinical decision-making. Fibrosis is ...
    • Molecular MRI of Collagen to Diagnose and Stage Liver Fibrosis 

      Fuchs, Bryan C.; Wang, Huifang; Yang, Yanfei; Wei, Lan; Polasek, Miloslav; Schühle, Daniel T.; Lauwers, Gregory Y.; Parkar, Ashfaq; Sinskey, Anthony J.; Tanabe, Kenneth Kenji; Caravan, Peter D. (Elsevier BV, 2013)
      Background & Aims The gold standard in assessing liver fibrosis is biopsy despite limitations like invasiveness and sampling error and complications including morbidity and mortality. Therefore, there is a major unmet ...
    • Mouse Model of Carbon Tetrachloride Induced Liver Fibrosis: Histopathological Changes and Expression of CD133 and Epidermal Growth Factor 

      Fujii, Tsutomu; Fuchs, Bryan C.; Yamada, Suguru; Lauwers, Gregory Y.; Kulu, Yakup; Goodwin, Jonathan M; Lanuti, Michael; Tanabe, Kenneth Kenji (BioMed Central, 2010)
      Background: In the setting of chronic liver injury in humans, epidermal growth factor (EGF) and EGF receptor (EGFR) are up-regulated and have been proposed to have vital roles in both liver regeneration and development of ...
    • The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy 

      Kim, Rosa S.; Hasegawa, Daisuke; Goossens, Nicolas; Tsuchida, Takuma; Athwal, Varinder; Sun, Xiaochen; Robinson, Christopher L.; Bhattacharya, Dipankar; Chou, Hsin-I; Zhang, David Y.; Fuchs, Bryan C.; Lee, Youngmin; Hoshida, Yujin; Friedman, Scott L. (Nature Publishing Group, 2016)
      Autophagy and the unfolded protein response (UPR) both promote activation of hepatic stellate cells (HSC), however the link between the two stimuli remains unclear. Here we have explored the role of X-box binding protein ...