Browsing by Author "Nussenzweig, André"

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    • Loss of ATM kinase activity leads to embryonic lethality in mice 

      Daniel, Jeremy A.; Pellegrini, Manuela; Lee, Baeck-Seung; Guo, Zhi; Filsuf, Darius; Belkina, Natalya V.; You, Zhongsheng; Paull, Tanya T.; Sleckman, Barry P.; Feigenbaum, Lionel; Nussenzweig, André (The Rockefeller University Press, 2012)
      Ataxia telangiectasia (A-T) mutated (ATM) is a key deoxyribonucleic acid (DNA) damage signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis. The majority of patients with A-T, a cancer-prone ...

    • Repeat expansions confer WRN dependence in microsatellite-unstable cancers 

      van Wietmarschen, Niek; Sridharan, Sriram; Nathan, William J.; Tubbs, Anthony; Chan, Edmond; Callen, Elsa; Wu, Wei; Belinky, Frida; Tripathi, Veenu; Wong, Nancy; Foster, Kyla; Noorbakhsh, Javad; Garimella, Kiran; Cruz-Migoni, Abimael; Sommers, Joshua A.; Huang, Yongqing; Borah, Ashir A.; Smith, Jonathan T.; Kalfon, Jeremie; Kesten, Nikolas; Fugger, Kasper; Walker, Robert L.; Dolzhenko, Egor; Eberle, Michael A.; Hayward, Bruce E.; Usdin, Karen; Freudenreich, Catherine H.; Brosh, Robert M.; West, Stephen C.; McHugh, Peter J.; Meltzer, Paul S.; Bass, Adam; Nussenzweig, André (Springer Science and Business Media LLC, 2020-09-30)
      The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair. Depletion of WRN induces widespread ...

    • Replication Fork Stability Confers Chemoresistance in BRCA-deficient Cells 

      Chaudhuri, Arnab Ray; Callen, Elsa; Ding, Xia; Gogola, Ewa; Duarte, Alexandra A.; Lee, Ji-Eun; Wong, Nancy; Lafarga, Vanessa; Calvo, Jennifer A.; Panzarino, Nicholas J.; John, Sam; Day, Amanda; Crespo, Anna Vidal; Shen, Binghui; Starnes, Linda M.; de Ruiter, Julian R.; Daniel, Jeremy A.; Konstantinopoulos, Panagiotis A.; Cortez, David; Cantor, Sharon B.; Fernandez-Capetillo, Oscar; Ge, Kai; Jonkers, Jos; Rottenberg, Sven; Sharan, Shyam K.; Nussenzweig, André (2016)
      Brca1- and Brca2-deficient cells have reduced capacity to repair DNA double-strand breaks (DSBs) by homologous recombination (HR) and consequently are hypersensitive to DNA damaging agents, including cisplatin and ...