Now showing items 1-14 of 14

    • A Bio-Inspired Swellable Microneedle Adhesive for Mechanical Interlocking with Tissue 

      Yang, Seung Yun; O'Cearbhaill, Eoin D.; Sisk, Geoffroy C.; Park, Kyeng Min; Cho, Woo Kyung; Villiger, Martin; Bouma, Brett E.; Pomahac, Bohdan; Karp, Jeffrey M. (2013)
      Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant ...
    • Co-Registered Spectrally Encoded Confocal Microscopy and Optical Frequency Domain Imaging System 

      Kang, D.K.; Suter, Melissa; Boudoux, Caroline; Yachimski, P.S.; Puricelli, W.P.; Nishioka, Norman Shizuaki; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo James (Wiley-Blackwell, 2010)
      Spectrally encoded confocal microscopy and optical frequency domain imaging are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for ...
    • Comprehensive Imaging of Gastroesophageal Biopsy Samples by Spectrally Encoded Confocal Microscopy 

      Kang, DongKyun; Suter, Melissa; Boudoux, Caroline; Yoo, Hongki; Yachimski, Patrick S.; Puricelli, William P.; Nishioka, Norman Shizuaki; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo James (Elsevier BV, 2010)
      Background: Spectrally encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy technique that has the potential to be used for acquiring comprehensive images of the entire distal esophagus ...
    • Comprehensive Microscopy of the Esophagus in Human Patients with Optical Frequency Domain Imaging 

      Suter, Melissa; Vakoc, Benjamin; Yachimski, Patrick S.; Shishkov, Milen Stefanov; Lauwers, Gregory Y.; Mino-Kenudson, Mari; Bouma, Brett; Nishioka, Norman Shizuaki; Tearney, Guillermo James (Elsevier BV, 2008)
      Background: Optical coherence tomography (OCT) is a cross-sectional, high-resolution imaging modality that has been shown to accurately differentiate esophageal specialized intestinal metaplasia (SIM) from gastric cardia ...
    • Comprehensive Volumetric Confocal Microscopy with Adaptive Focusing 

      Kang, DongKyun; Yoo, Hongki; Jillella, Priyanka; Bouma, Brett; Tearney, Guillermo James (Optical Society of America, 2011)
      Comprehensive microscopy of distal esophagus could greatly improve the screening and surveillance of esophageal diseases such as Barrett’s esophagus by providing histomorphologic information over the entire region at risk. ...
    • Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour 

      Villiger, Martin; Lorenser, Dirk; McLaughlin, Robert A.; Quirk, Bryden C.; Kirk, Rodney W.; Bouma, Brett E.; Sampson, David D. (Nature Publishing Group, 2016)
      Identifying tumour margins during breast-conserving surgeries is a persistent challenge. We have previously developed miniature needle probes that could enable intraoperative volume imaging with optical coherence tomography. ...
    • Dual-Modality Fluorescence and Full-Field Optical Coherence Microscopy for Biomedical Imaging Applications 

      Auksorius, Egidijus; Bromberg, Yaron; Motiejūnaitė, Rūta; Pieretti, Alberto Christian; Liu, Linbo; Coron, Emmanuel; Aranda, Jorge; Goldstein, Allan Moises; Bouma, Brett; Kazlauskas, Andrius; Tearney, Guillermo James (Optical Society of America, 2012)
      Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence ...
    • Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance 

      Tan, K.M.; Shishkov, Milen Stefanov; Chee, A.; Applegate, M. B.; Bouma, Brett; Suter, Melissa (Optical Society of America, 2012)
      Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have ...
    • GPU-Accelerated Framework for Intracoronary Optical Coherence Tomography Imaging at the Push of a Button 

      Han, Myounghee; Kim, Kyunghun; Jang, Sun-Joo; Cho, Han Saem; Bouma, Brett E.; Oh, Wang-Yuhl; Ryu, Sukyoung (Public Library of Science, 2015)
      Frequency domain optical coherence tomography (FD-OCT) has become one of the important clinical tools for intracoronary imaging to diagnose and monitor coronary artery disease, which has been one of the leading causes of ...
    • Identifying Intestinal Metaplasia at the Squamocolumnar Junction by Using Optical Coherence Tomography 

      Evans, John A.; Bouma, Brett; Bressner, Jason; Shishkov, Milen Stefanov; Lauwers, Gregory Y.; Mino-Kenudson, Mari; Nishioka, Norman Shizuaki; Tearney, Guillermo James (Elsevier BV, 2007)
      Background: Optical coherence tomography (OCT) is an optical imaging method that produces high-resolution cross-sectional images of the esophagus. The accuracy of OCT for differentiating tissue types at the squamocolumnar ...
    • Image-Guided Biopsy in the Esophagus through Comprehensive Optical Frequency Domain Imaging and Laser Marking: A Study in Living Swine 

      Suter, Melissa; Jillella, Priyanka A.; Vakoc, Benjamin; Halpern, Elkan F.; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Nishioka, Norman Shizuaki; Tearney, Guillermo James (Elsevier BV, 2010)
      Background: Random biopsy esophageal surveillance can be subject to sampling errors, resulting in diagnostic uncertainty. Optical frequency domain imaging (OFDI) is a high-speed, 3-dimensional endoscopic microscopy technique. ...
    • In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography 

      Blatter, Cedric; Meijer, Eelco F. J.; Nam, Ahhyun S.; Jones, Dennis; Bouma, Brett E.; Padera, Timothy P.; Vakoc, Benjamin J. (Nature Publishing Group, 2016)
      Direct in vivo imaging of lymph flow is key to understanding lymphatic system function in normal and disease states. Optical microscopy techniques provide the resolution required for these measurements, but existing optical ...
    • Reflectance Confocal Microscopy for the Diagnosis of Eosinophilic Esophagitis: a Pilot Study Conducted on Biopsy Specimens 

      Yoo, Hongki; Kang, DongKyun; Katz, Aubrey J.; Lauwers, Gregory Y.; Nishioka, Norman Shizuaki; Yagi, Yukako; Tanpowpong, Pornthep; Namati, Jacqueline; Bouma, Brett; Tearney, Guillermo James (Elsevier BV, 2011)
      Background: Diagnosis of eosinophilic esophagitis (EoE) currently requires endoscopic biopsy and histopathologic analysis of the biopsy specimens to count intraepithelial eosinophils. Reflectance confocal microscopy (RCM) ...
    • Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure 

      Gora, Michalina J.; Sauk, Jenny S.; Carruth, Robert W.; Gallagher, Kevin A.; Suter, Melissa J.; Nishioka, Norman S.; Kava, Lauren E.; Rosenberg, Mireille; Bouma, Brett E.; Tearney, Guillermo J. (2012)
      Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut ...