Browsing by Author "Lu, Quan"

Now showing items 1-8 of 8

    • Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals 

      Rodosthenous, Rodosthenis S.; Coull, Brent A.; Lu, Quan; Vokonas, Pantel S.; Schwartz, Joel D.; Baccarelli, Andrea A. (BioMed Central, 2016)
      Background: Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) ...

    • Exploring the role of microRNAs in airway smooth muscle biology and asthma therapy 

      Hu, Ruoxi (2014-06-06)
      The pathophysiology of asthma is characterized by airway inflammation, remodeling and hyper-responsiveness. Phenotypic changes in airway smooth muscle cells (ASM) play a pivotal role in the pathogenesis of asthma. ASM cells ...

    • Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes 

      Pan, Wen-Chi; Kile, Molly L.; Seow, Wei Jie; Lin, Xihong; Quamruzzaman, Quazi; Rahman, Mahmuder; Mahiuddin, Golam; Mostofa, Golam; Lu, Quan; Christiani, David C. (Public Library of Science, 2013)
      Background: Chronic exposure to arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM) but the underlying molecular mechanism remains unclear. Objectives: This study evaluated the ...

    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...

    • A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases 

      Zhu, Zhaozhong; Lee, Phil Hyoun; Chaffin, Mark; Chung, Wonil; Loh, Po-Ru; Lu, Quan; Christiani, David Christopher; Liang, Liming (Springer Science and Business Media LLC, 2018-05-21)
      Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and ...

    • Genome-Wide RNAi Screen in \(IFN-\gamma-Treated\) Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis 

      Zhou, Hongwei; Browning, Erica; Tan, Fengxiao; Imrich, Amy; Kramnik, Igor; Gregory, David James; Koziel, Henryk; Lu, Quan; Kobzik, Lester; DeLoid, Glen M.; Bedugnis, Alice (Public Library of Science, 2012)
      Interferon-gamma \((IFN-\gamma)\) inhibits intracellular replication of Francisella tularensis in human monocyte-derived macrophages (HMDM) and in mice, but the mechanisms of this protective effect are poorly characterized. ...

    • Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma 

      McGeachie, Michael John; Yates, Katherine; Zhou, Xiaobo; Guo, Feng; Sternberg, Alice L.; Van Natta, Mark L.; Wise, Robert A.; Szefler, Stanley J.; Sharma, Sunita; Kho, Alvin Thong-Juak; Cho, Michael Hyosang; Croteau-Chonka, Damien C; Castaldi, Peter Jose; Jain, Gaurav; Sanyal, Amartya; Zhan, Ye; Lajoie, Bryan R.; Dekker, Job; Stamatoyannopoulos, John; Covar, Ronina A.; Zeiger, Robert S.; Adkinson, N. Franklin; Williams, Paul; Kelly, H. William; Grasemann, Hartmut; Vonk, Judith M.; Koppelman, Gerard H.; Postma, Dirkje S.; Raby, Benjamin Alexander; Houston, Isaac Benjamin; Lu, Quan; Fuhlbrigge, Anne Louise; Tantisira, Kelan; Silverman, Edwin Kepner; Tonascia, James; Weiss, Scott Tillman; Strunk, Robert C. (New England Journal of Medicine (NEJM/MMS), 2016)
      BACKGROUND: Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS: We ...

    • RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells 

      Himes, Blanca E.; Jiang, Xiaofeng; Wagner, Peter; Hu, Ruoxi; Wang, Qiyu; Klanderman, Barbara; Whitaker, Reid M.; Duan, Qingling; Lasky-Su, Jessica; Nikolos, Christina; Jester, William; Johnson, Martin; Panettieri, Reynold A.; Tantisira, Kelan G.; Weiss, Scott T.; Lu, Quan (Public Library of Science, 2014)
      Asthma is a chronic inflammatory respiratory disease that affects over 300 million people worldwide. Glucocorticoids are a mainstay therapy for asthma because they exert anti-inflammatory effects in multiple lung tissues, ...