Now showing items 1-15 of 15

    • A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis 

      Klein, Joshua Peter; Arora, A.; Neema, M; Healy, Brian Curran; Tauhid, Shahamat Syed; Goldberg-Zimring, D.; Chavarro-Nieto, C.; Stankiewicz, James; Cohen, Adam Brian; Buckle, G. J.; Houtchens, Maria K.; Ceccarelli, A.; Dell, E.; Guttmann, Charles R.G.; Alsop, David C.; Hackney, David Brian; Bakshi, Rohit (American Society of Neuroradiology (ASNR), 2011)
      Background and Purpose: Spinal cord atrophy is a common feature of MS. However, it is unknown which cord levels are most susceptible to atrophy. We performed whole cord imaging to identify the levels most susceptible to ...
    • Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis 

      Stankiewicz, James; Glanz, Bonnie; Healy, Brian Curran; Arora, Ashish; Neema, Mohit; Benedict, Ralph H.B.; Guss, Zachary D.; Tauhid, Shahamat Syed; Buckle, Guy J.; Houtchens, Maria K.; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit (Wiley-Blackwell, 2011)
      Background/Purpose: To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). Methods: Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed ...
    • Brain MRI lesions and atrophy are associated with employment status in patients with multiple sclerosis 

      Tauhid, Shahamat; Chu, Renxin; Sasane, Rahul; Glanz, Bonnie I.; Neema, Mohit; Miller, Jennifer R.; Kim, Gloria; Signorovitch, James E.; Healy, Brian C.; Chitnis, Tanuja; Weiner, Howard L.; Bakshi, Rohit (Springer Berlin Heidelberg, 2015)
      Multiple sclerosis (MS) commonly affects occupational function. We investigated the link between brain MRI and employment status. Patients with MS (n = 100) completed a Work Productivity and Activity Impairment (WPAI) ...
    • The Contribution of Cortical Lesions to a Composite MRI Scale of Disease Severity in Multiple Sclerosis 

      Yousuf, Fawad; Kim, Gloria; Tauhid, Shahamat; Glanz, Bonnie I.; Chu, Renxin; Tummala, Subhash; Healy, Brian C.; Bakshi, Rohit (Frontiers Media S.A., 2016)
      Objective: To test a new version of the Magnetic Resonance Disease Severity Scale (v.3 = MRDSS3) for multiple sclerosis (MS), incorporating cortical gray matter lesions (CLs) from 3T magnetic resonance imaging (MRI). ...
    • The Effect of Dimethyl Fumarate on Cerebral Gray Matter Atrophy in Multiple Sclerosis 

      Dupuy, Sheena L.; Tauhid, Shahamat; Hurwitz, Shelley; Chu, Renxin; Yousuf, Fawad; Bakshi, Rohit (Springer Healthcare, 2016)
      Introduction: The objective of this pilot study was to compare cerebral gray matter (GM) atrophy over 1 year in patients starting dimethyl fumarate (DMF) for multiple sclerosis (MS) to that of patients on no disease-modifying ...
    • The Effect of Fingolimod on Conversion of Acute Gadolinium-Enhancing Lesions to Chronic T1 Hypointensities in Multiple Sclerosis 

      Oommen Vinit, V; Tauhid, Shahamat; Healy Brian, C; Chua Alicia, S; Malik, MT; Diaz-Cruz, Camilo; Dupuy Sheena, L; Weiner Howard, L; Chitnis, Tanuja; Bakshi, Rohit (Wiley-Blackwell, 2015)
      BACKGROUND: Brain lesions converting to chronic T1 hypointensities (“chronic black holes” [CBH]), indicate severe tissue destruction (axonal loss and irreversible demyelination) in multiple sclerosis (MS). Two mechanisms ...
    • The effect of intramuscular interferon beta-1a on spinal cord volume in relapsing-remitting multiple sclerosis 

      Dupuy, Sheena L.; Khalid, Fariha; Healy, Brian C.; Bakshi, Sonya; Neema, Mohit; Tauhid, Shahamat; Bakshi, Rohit (BioMed Central, 2016)
      Background: Spinal cord atrophy occurs early in multiple sclerosis (MS) and impacts disability. The therapeutic effect of interferon beta-1a (IFNβ-1a) on spinal cord atrophy in patients with relapsing-remitting (RR) MS has ...
    • An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2 

      Bakshi, Rohit; Neema, Mohit; Tauhid, Shahamat; Healy, Brian C.; Glanz, Bonnie I.; Kim, Gloria; Miller, Jennifer; Berkowitz, Julia L.; Bove, Riley; Houtchens, Maria K.; Severson, Christopher; Stankiewicz, James M.; Stazzone, Lynn; Chitnis, Tanuja; Guttmann, Charles R.G.; Weiner, Howard L.; Ceccarelli, Antonia (Lippincott Williams & Wilkins, 2014)
      The objective of this study was to test a new version of the Magnetic Resonance Disease Severity Scale (MRDSS2), incorporating cerebral gray matter (GM) and spinal cord involvement from 3 T MRI, in modeling the relationship ...
    • MRI detection of hypointense brain lesions in patients with multiple sclerosis: T1 spin-echo vs. gradient-echo 

      Dupuy, Sheena; Tauhid, Shahamat Syed; Kim, Gloria; Chu, Renxin; Tummala, Subhash; Hurwitz, Shelley; Bakshi, Rohit (Elsevier BV, 2015)
      Objective Compare T1 spin-echo (T1SE) and T1 gradient-echo (T1GE) sequences in detecting hypointense brain lesions in multiple sclerosis (MS). Background Chronic hypointense lesions on T1SE MRI scans are a surrogate ...
    • MRI phenotypes based on cerebral lesions and atrophy in patients with multiple sclerosis 

      Tauhid, Shahamat Syed; Neema, Mohit; Healy, Brian Curran; Weiner, Howard Lee; Bakshi, Rohit (Elsevier BV, 2014)
      Background: While disease categories (i.e. clinical phenotypes) of multiple sclerosis (MS) are established, there remains MRI heterogeneity among patients within those definitions. MRI-defined lesions and atrophy show only ...
    • An MRI-defined measure of cerebral lesion severity to assess therapeutic effects in multiple sclerosis 

      Kim, Gloria; Tauhid, Shahamat; Dupuy, Sheena L.; Tummala, Subhash; Khalid, Fariha; Healy, Brian C.; Bakshi, Rohit (Springer Berlin Heidelberg, 2016)
      Assess the sensitivity of the Magnetic Resonance Disease Severity Scale (MRDSS), based on cerebral lesions and atrophy, for treatment monitoring of glatiramer acetate (GA) in relapsing-remitting multiple sclerosis (MS). ...
    • Quantification of Global Cerebral Atrophy in Multiple Sclerosis from 3T MRI Using SPM: The Role of Misclassification Errors 

      Dell’Oglio, Elisa; Ceccarelli, Antonia; Glanz, Bonnie I; Healy, Brian C; Tauhid, Shahamat; Arora, Ashish; Saravanan, Nikila; Bruha, Matthew J; Vartanian, Alexander V; Dupuy, Sheena L; Benedict, Ralph HB; Bakshi, Rohit; Neema, Mohit (BlackWell Publishing Ltd, 2014)
      Purpose We tested the validity of a freely available segmentation pipeline to measure compartmental brain volumes from 3T MRI in patients with multiple sclerosis (MS). Our primary focus was methodological to explore the ...
    • Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis 

      Bakshi, Rohit; Yeste, A; Patel, B.; Tauhid, Shahamat Syed; Tummala, Subhash; Rahbari, R.; Chu, Renxin; Regev, Keren; Kivisakk, Pia; Weiner, Howard Lee; Quintana, Francisco Javier (Ovid Technologies (Wolters Kluwer Health), 2016)
      Objective: To determine whether peripheral immune responses as measured by serum antigen arrays are linked to cerebral MRI measures of disease severity in multiple sclerosis (MS). Methods: In this cross-sectional study, ...
    • T1- vs. T2-based MRI measures of spinal cord volume in healthy subjects and patients with multiple sclerosis 

      Kim, Gloria; Khalid, Fariha; Oommen, Vinit V.; Tauhid, Shahamat; Chu, Renxin; Horsfield, Mark A.; Healy, Brian C.; Bakshi, Rohit (BioMed Central, 2015)
      Background: The reliable and efficient measurement of spinal cord atrophy is of growing interest in monitoring disease progression in multiple sclerosis (MS). Methods: We compared T1- and T2-weighted MRI for measuring ...
    • Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis 

      Chu, Renxin; Tauhid, Shahamat Syed; Glanz, Bonnie; Healy, Brian Curran; Kim, Gloria; Oommen, Vinit V.; Khalid, Fariha; Neema, Mohit; Bakshi, Rohit (Wiley-Blackwell, 2015)
      Background: Whole brain atrophy is a putative outcome measure in monitoring relapsing-remitting multiple sclerosis (RRMS). With the ongoing MRI transformation from 1.5T to 3T, there is an unmet need to calibrate this change. ...