Browsing by Author "Adamson, Brittany Susan"
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A Bioinformatics Method Identifies Prominent Off-targeted Transcripts in RNAi Screens
Sigoillot, Frederic D.; Lyman, Susan; Huckins, Jeremy F.; Adamson, Brittany Susan; Chung, Eunah; Quattrochi, Brian; King, Randall Wharton (Nature Publishing Group, 2012)Because off-target effects hamper interpretation and validation of RNAi screens, we developed a bioinformatics method, Genome-wide Enrichment of Seed Sequence matches (GESS), to identify candidate off-targeted transcripts ... -
A Genome-Wide Study of Homologous Recombination in Mammalian Cells Identifies RBMX, a Novel Component of the DNA Damage Response
Adamson, Brittany Susan (2013-03-20)Repair of DNA double-strand breaks is critical to the maintenance of genomic stability, and failure to repair these DNA lesions can cause loss of chromosome telomeric regions, complex translocations, or cell death. In ...