Now showing items 1-3 of 3

    • DHODH modulates transcriptional elongation in the neural crest and melanoma 

      White, Richard Mark; Cech, Jennifer; Ratanasirintrawoot, Sutheera; Lin, Charles P.; Rahl, Peter B.; Burke, Christopher J.; Langdon, Erin; Tomlinson, Matthew L.; Mosher, Jack; Kaufman, Charles Kore; Chen, Frank; Long, Hannah K.; Kramer, Martin; Datta, Sumon Michael; Neuberg, Donna S.; Granter, Scott R.; Young, Richard A.; Morrison, Sean; Wheeler, Grant N.; Zon, Leonard Ira (Nature Publishing Group, 2011)
    • The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models 

      Yen, Jennifer; White, Richard M; Wedge, David C; Van Loo, Peter; de Ridder, Jeroen; Capper, Amy; Richardson, Jennifer; Jones, David; Raine, Keiran; Watson, Ian R; Wu, Chang-Jiun; Cheng, Jiqiu; Martincorena, Iñigo; Nik-Zainal, Serena; Mudie, Laura; Moreau, Yves; Marshall, John; Ramakrishna, Manasa; Tarpey, Patrick; Shlien, Adam; Whitmore, Ian; Gamble, Steve; Latimer, Calli; Langdon, Erin; Kaufman, Charles; Dovey, Mike; Taylor, Alison; Menzies, Andy; McLaren, Stuart; O’Meara, Sarah; Butler, Adam; Teague, Jon; Lister, James; Chin, Lynda; Campbell, Peter; Adams, David J; Zon, Leonard I; Patton, E Elizabeth; Stemple, Derek L; Futreal, P Andy (BioMed Central, 2013)
      Background: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. ...
    • Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish 

      Mosimann, Christian; Kaufman, Charles Kore; Li, Pulin; Pugach, Emily K.; Tamplin, Owen J.; Zon, Leonard Ira (The Company of Biologists, 2010)
      Molecular genetics approaches in zebrafish research are hampered by the lack of a ubiquitous transgene driver element that is active at all developmental stages. Here, we report the isolation and characterization of the ...