Browsing by Author "Lotinun, Sutada"

Now showing items 1-4 of 4

    • Deficiency of Retinaldehyde Dehydrogenase 1 Induces BMP2 and Increases Bone Mass In Vivo 

      Nallamshetty, Shriram; Wang, Hong; Rhee, Eun-Jung; Kiefer, Florian W.; Brown, Jonathan D.; Lotinun, Sutada; Le, Phuong; Baron, Roland; Rosen, Clifford J.; Plutzky, Jorge (Public Library of Science, 2013)
      The effects of retinoids, the structural derivatives of vitamin A (retinol), on post-natal peak bone density acquisition and skeletal remodeling are complex and compartment specific. Emerging data indicates that retinoids, ...

    • Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning 

      Saez, Borja; Ferraro, F.; Yusuf, Rushdia Zareen; Cook, Colleen M.; Yu, Vionnie Wing Chi; Pardo-Saganta, A.; Sykes, Stephen M.; Palchaudhuri, Rahul; Schajnovitz, Amir; Lotinun, S; Lymperi, Stefania; Mendez-Ferrer, Simon; del Toro, Raquel; Day, Robyn Rouviere; Vasic, Radovan; Acharya, Sanket Shyamkant; Baron, Roland; Lin, Charles P.; Yamaguchi, Yu; Wagers, Amy Jo; Scadden, David Thomas (American Society of Hematology, 2014)
      The glycosyltransferase gene, Ext1, is essential for heparan sulfate production. Induced deletion of Ext1 selectively in Mx1-expressing bone marrow (BM) stromal cells, a known population of skeletal stem/progenitor cells, ...

    • The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2 

      Zou, Weiguo; Greenblatt, Matthew B.; Brady, Nicholas; Lotinun, Sutada; Zhai, Bo; de Rivera, Heather; Singh, Anju; Sun, Jun; Gygi, Steven P.; Baron, Roland; Glimcher, Laurie H.; Jones, Dallas C. (The Rockefeller University Press, 2013)
      Osteoblasts are responsible for the formation and mineralization of the skeleton. To identify novel regulators of osteoblast differentiation, we conducted an unbiased forward genetic screen using a lentiviral-based shRNA ...

    • SIRT1 Regulates Differentiation of Mesenchymal Stem Cells by Deacetylating β-Catenin 

      Simic, Petra; Zainabadi, Kayvan; Bell, Eric; Sykes, David Brian; Saez, Borja; Lotinun, Sutada; Baron, Roland; Scadden, David Thomas; Schipani, Ernestina; Guarente, Leonard (WILEY-VCH Verlag, 2013)
      Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a ...