Browsing by Author "Thoreen, Carson"

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    • A Unifying Model for mTORC1-Mediated Regulation of mRNA Translation 

      Thoreen, Carson; Chantranupong, Lynne; Keys, Heather R.; Wang, Tim; Gray, Nathanael Schiander; Sabatini, David M. (Nature Publishing Group, 2012)
      The mTOR Complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin, a drug with many clinical uses1. mTORC1 regulates mRNA translation, but the overall ...