Browsing by Author "Zurakowski, David"
Now showing items 1-18 of 18
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Acute seizure suppression by transcranial direct current stimulation in rats
Dhamne, Sameer C; Ekstein, Dana; Zhuo, Zhihong; Gersner, Roman; Zurakowski, David; Loddenkemper, Tobias; Pascual-Leone, Alvaro; Jensen, Frances E; Rotenberg, Alexander (John Wiley & Sons, Ltd, 2015)Objective: Cathodal transcranial direct current stimulation (tDCS) is a focal neuromodulation technique that suppresses cortical excitability by low-amplitude constant electrical current, and may have an antiepileptic ... -
Assessment of axial bone rigidity in rats with metabolic diseases using CT-based structural rigidity analysis
Smith, M. D.; Baldassarri, S.; Anez-Bustillos, L.; Tseng, A.; Entezari, V.; Zurakowski, David; Snyder, Brian Dale; Nazarian, Ara (British Editorial Society of Bone and Joint Surgery, 2012)Objectives: This study aims to assess the correlation of CT-based structural rigidity analysis with mechanically determined axial rigidity in normal and metabolically diseased rat bone. Methods: A total of 30 rats were ... -
Circulating Endothelial Progenitor Cells Are Up-Regulated in a Mouse Model of Endometriosis
Becker, Christian M.; Beaudry, Paul; Funakoshi, Tae; Benny, Ofra; Zaslavsky, Alexander; Zurakowski, David; Folkman, Judah; D\'Amato, Robert J.; Ryeom, Sandra (American Society for Investigative Pathology, 2011)Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that angiogenesis plays an integral part in the establishment and growth of endometriotic lesions. ... -
Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer
Brauner, Eran; Gunda, Viswanath; Borre, Pierre Vanden; Zurakowski, David; Kim, Yon Seon; Dennett, Kate Virginia; Amin, Salma; Freeman, Gordon James; Parangi, Sareh (Impact Journals LLC, 2016)The interaction of programmed cell death-1 and its ligand is widely studied in cancer. Monoclonal antibodies blocking these molecules have had great success but little is known about them in thyroid cancer. We investigated ... -
The Effect of Perioperative Ketorolac on the Clinical Failure Rate of Meniscal Repair
Proffen, Benedikt L.; Nielson, Jason H.; Zurakowski, David; Micheli, Lyle J.; Curtis, Christine; Murray, Martha M. (2014)Background: There has been recent interest in the effect of nonsteroidal anti-inflammatory medications on musculoskeletal healing. No studies have yet addressed the effect of these medications on meniscal healing. Hypothesis ... -
Evidence-based decision support for pediatric rheumatology reduces diagnostic errors
Segal, Michael M.; Athreya, Balu; Son, Mary Beth F.; Tirosh, Irit; Hausmann, Jonathan S.; Ang, Elizabeth Y. N.; Zurakowski, David; Feldman, Lynn K.; Sundel, Robert P. (BioMed Central, 2016)Background: The number of trained specialists world-wide is insufficient to serve all children with pediatric rheumatologic disorders, even in the countries with robust medical resources. We evaluated the potential of ... -
Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study
Lo, Mindy S; Zurakowski, David; Son, Mary Beth F; Sundel, Robert P (BioMed Central, 2013)Background: The significance of hypergammaglobulinemia as a marker of immune activation is unknown, as a differential diagnosis for hypergammaglobulinemia in children has not been adequately established. The goal of this ... -
Inhaled Carbon Monoxide Provides Cerebral Cytoprotection in Pigs
Mahan, Vicki L.; Zurakowski, David; Otterbein, Leo E.; Pigula, Frank Alexander (Public Library of Science, 2012)Carbon monoxide (CO) at low concentrations imparts protective effects in numerous preclinical small animal models of brain injury. Evidence of protection in large animal models of cerebral injury, however, has not been ... -
Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection
Cowan, Douglas B.; Yao, Rouan; Akurathi, Vamsidhar; Snay, Erin R.; Thedsanamoorthy, Jerusha K.; Zurakowski, David; Ericsson, Maria; Friehs, Ingeborg; Wu, Yaotang; Levitsky, Sidney; del Nido, Pedro J.; Packard, Alan B.; McCully, James D. (Public Library of Science, 2016)We have previously shown that transplantation of autologously derived, respiration-competent mitochondria by direct injection into the heart following transient ischemia and reperfusion enhances cell viability and contractile ... -
Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry
Henderson, Lauren A.; Zurakowski, David; Angeles-Han, Sheila T.; Lasky, Andrew; Rabinovich, C. Egla; Lo, Mindy S. (BioMed Central, 2016)Background: There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a ... -
A Modern Cohort of Duodenal Obstruction Patients: Predictors of Delayed Transition to Full Enteral Nutrition
Bairdain, Sigrid; Yu, David C.; Lien, Chueh; Khan, Faraz Ali; Pathak, Bhavana; Grabowski, Matthew J.; Zurakowski, David; Linden, Bradley C. (Hindawi Publishing Corporation, 2014)Background:. A common site for neonatal intestinal obstruction is the duodenum. Delayed establishment of enteral nutritional autonomy continues to challenge surgeons and, since early institution of nutritional support is ... -
NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction
Als, Heidelise; Duffy, Frank Hopkins; McAnulty, Gloria; Butler, Samantha C.; Lightbody, L; Kosta, S; Weisenfeld, Neil I; Robertson, Richard Lee; Parad, Richard Barry; Ringer, Steven Alan; Blickman, J G; Zurakowski, David; Warfield, Simon Keith (Nature Publishing Group, 2012)Objective: The effect of NIDCAP (Newborn Individualized Developmental Care and Assessment Program) was examined on the neurobehavioral, electrophysiological and neurostructural development of preterm infants with severe ... -
Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study
Cornelissen, Laura; Donado, Carolina; Kim, Joseph; Chiel, Laura; Zurakowski, David; Logan, Deirdre E; Meier, Petra; Sethna, Navil F; Blankenburg, Markus; Zernikow, Boris; Sundel, Robert P; Berde, Charles B (BioMed Central, 2014)Background: Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies ... -
A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia
Lobo, Kimberly; Donado, Carolina; Cornelissen, Laura Louise; Kim, Joseph; Ortiz, Rebeca; Peake, Roy; Kellogg, Mark David; Alexander, Mark Edward; Zurakowski, David; Kurgansky, Katherine E.; Peyton, James Matthew; Bilge, Aykut; Boretsky, Karen Rach; McCann, Mary Ellen; Berde, Charles Benjamin; Cravero, Joseph Peter (Ovid Technologies (Wolters Kluwer Health), 2015)BACKGROUND: Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, ... -
School-age effects of the newborn individualized developmental care and assessment program for preterm infants with intrauterine growth restriction: preliminary findings
McAnulty, Gloria; Duffy, Frank Hopkins; Kosta, Sandra; Weisenfeld, Neil I; Warfield, Simon Keith; Butler, Samantha C.; Alidoost, Moona; Bernstein, Jane Holmes; Robertson, Richard Lee; Zurakowski, David; Als, Heidelise (BioMed Central, 2013)Background: The experience in the newborn intensive care nursery results in premature infants’ neurobehavioral and neurophysiological dysfunction and poorer brain structure. Preterms with severe intrauterine growth restriction ... -
Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia
Berde, Charles Benjamin; Athiraman, Umeshkumar; Yahalom, Barak; Zurakowski, David; Corfas, Gabriel; Bognet, Christina (Molecular Diversity Preservation International (MDPI), 2011)Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, ... -
Training dual-task walking in community-dwelling adults within 1 year of stroke: A protocol for a single-blind randomized controlled trial
Plummer-D’Amato, Prudence; Kyvelidou, Anastasia; Sternad, Dagmar; Najafi, Bijan; Villalobos, Raymond M; Zurakowski, David (BioMed Central, 2012)Background: Community ambulation is a highly complex skill requiring the ability to adapt to increased environmental complexity and perform multiple tasks simultaneously. After stroke, individuals demonstrate a diminished ... -
Transient alterations of cutaneous sensory nerve function by non-invasive cryolipolysis
Garibyan, Lilit; Cornelissen, Laura; Sipprell, William; Pruessner, Joachim; Elmariah, Sarina; Luo, Tuan; Lerner, Ethan A.; Jung, Yookyung; Evans, Conor; Zurakowski, David; Berde, Charles B.; Rox Anderson, R. (2015)Cryolipolysis is a non-invasive, skin cooling treatment for local fat reduction that causes prolonged hypoesthesia over the treated area. We tested the hypothesis that cryolipolysis can attenuate nociception of a range of ...