Now showing items 1-4 of 4

    • Discovery of Insect and Human Dengue Virus Host Factors 

      Sessions, October M.; Barrows, Nicholas J.; Souza-Neto, Jayme A.; Robinson, Timothy J.; Hershey, Christine L.; Rodgers, Mary A.; Ramirez, Jose L.; Dimopoulos, George; Yang, Priscilla; Pearson, James L.; Garcia-Blanco, Mariano A. (2012)
      Dengue fever (DF) is the most frequent arthropod-borne viral disease of humans, with almost half of the world's population at risk of infection. The high prevalence, lack of an effective vaccine, and absence of specific ...
    • Exploring Dengue Virus Entry through Small Molecule Inhibition and Mutagenesis of the Envelope Protein 

      Clark, Margaret Jean (2013-03-15)
      Over one-third of the world’s population is at risk for infection with dengue virus (DENV), a mosquito-borne virus that can cause a severe febrile disease. There are no specific treatments available for dengue infection, ...
    • Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate 

      Schmidt, Aaron Gregory; Yang, Priscilla; Harrison, Stephen C. (Public Library of Science, 2010)
      The mechanism of membrane fusion by “class II” viral fusion proteins follows a pathway that involves large-scale domain rearrangements of the envelope glycoprotein (E) and a transition from dimers to trimers. The rearrangement ...
    • Small-Molecule Inhibitors of Dengue-Virus Entry 

      Schmidt, Aaron Gregory; Lee, Kyungae; Yang, Priscilla; Harrison, Stephen C. (Public Library of Science, 2012)
      Flavivirus envelope protein (E) mediates membrane fusion and viral entry from endosomes. A low-pH induced, dimer-to-trimer rearrangement and reconfiguration of the membrane-proximal "stem" of the E ectodomain draw together ...