Now showing items 1-15 of 15

    • BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes 

      Cooper, Zachary A; Frederick, Dennie T; Juneja, Vikram R; Sullivan, Ryan J; Lawrence, Donald P; Piris, Adriano; Sharpe, Arlene H; Fisher, David E; Flaherty, Keith T; Wargo, Jennifer A (Landes Bioscience, 2013)
      There have been significant advances with regard to BRAF-targeted therapies against metastatic melanoma. However, the majority of patients receiving BRAF inhibitors (BRAFi) manifest disease progression within a year. We ...
    • Clinical Profiling of BCL-2 Family Members in the Setting of BRAF Inhibition Offers a Rationale for Targeting De Novo Resistance Using BH3 Mimetics 

      Frederick, Dennie T.; Salas Fragomeni, Roberto A.; Schalck, Aislyn; Ferreiro-Neira, Isabel; Hoff, Taylor; Cooper, Zachary A.; Haq, Rizwan; Panka, David J.; Kwong, Lawrence N.; Davies, Michael A.; Cusack, James C.; Flaherty, Keith T.; Fisher, David E.; Mier, James W.; Wargo, Jennifer A.; Sullivan, Ryan J. (Public Library of Science, 2014)
      While response rates to BRAF inhibitiors (BRAFi) are high, disease progression emerges quickly. One strategy to delay the onset of resistance is to target anti-apoptotic proteins such as BCL-2, known to be associated with ...
    • Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 

      Yoon, K. W.; Byun, S.; Kwon, Eunjeong; Hwang, So-Young; Chu, Kiki; Hiraki, Masatsugu; Jo, Seung-Hee; Weins, Astrid; Hakroush, Samy; Cebulla, Angelika; Sykes, David Brian; Greka, Anna; Mundel, Peter; Fisher, David E.; Mandinova, Anna; Lee, Sam Whan (American Association for the Advancement of Science (AAAS), 2015)
      The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor suppressor p53 controls signaling-mediated phagocytosis of ...
    • Cutaneous Biology and Endogenous Opioids: How the Skin Modulates Pain and Addiction 

      Robinson, Kathleen Clare (2014-02-25)
      The Proopiomelanocortin gene, (POMC), produces many biologically active peptides including the endogenous opioid, β-endorphin, and the melanocortins: α-Melanocyte Stimulating Hormone, (αMSH), γMSH, ...
    • Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma 

      Jalili, Ahmad; Wagner, Christine; Pashenkov, Mikhail; Pathria, Gaurav; Mertz, Kirsten D.; Widlund, Hans R.; Lupien, Mathieu; Brunet, Jean- Philippe; Golub, Todd R.; Stingl, Georg; Fisher, David Erich; Ramaswamy, Sridhar; Wagner, Stephan N. (Oxford University Press, 2012)
      Resistance to BRAFV600E inhibitors is associated with reactivation of mitogen-activated protein kinase (MAPK) signaling at different levels in melanoma. To identify downstream effectors of MAPK signaling that could be used ...
    • Epigenetic shielding: 5-hydroxymethylcytosine and 5-carboxylcytosine modulate UV induction of DNA photoproducts 

      Liu, Jue Judy (2014-06-06)
      Maintaining the balance between dynamic DNA methylation and demethylation is crucial to mammalian development and pathogenesis. In vitro methylation at the C-5 position of cytosine enhances cyclobutane pyrimidine dimer ...
    • Immunotherapy in the Precision Medicine Era: Melanoma and Beyond 

      Su, Mack Y.; Fisher, David E. (Public Library of Science, 2016)
      In a Perspective, Mack Su and David Fisher discuss the development of immunotherapies for treatment of melanoma and other cancer types.
    • The Impact of MITF on Melanoma Development – News from Bench and Bedside 

      Roider, Elisabeth; Fisher, David E. (2013)
      Summary In the current issue, two articles highlight the impact of MITF on melanoma development. In the first, Lister et al. (2013) reveal in vivo proof of MITF directly regulating tumor development in BRAFV600E melanomas. ...
    • In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin 

      Wang, Hequn; Osseiran, Sam; Igras, Vivien; Nichols, Alexander J.; Roider, Elisabeth M.; Pruessner, Joachim; Tsao, Hensin; Fisher, David E.; Evans, Conor L. (Nature Publishing Group, 2016)
      Melanoma is the most deadly form of skin cancer with a yearly global incidence over 232,000 patients. Individuals with fair skin and red hair exhibit the highest risk for developing melanoma, with evidence suggesting the ...
    • Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment 

      Friedman, Adam A.; Amzallag, Arnaud; Pruteanu-Malinici, Iulian; Baniya, Subash; Cooper, Zachary A.; Piris, Adriano; Hargreaves, Leeza; Igras, Vivien; Frederick, Dennie T.; Lawrence, Donald P.; Haber, Daniel A.; Flaherty, Keith T.; Wargo, Jennifer A.; Ramaswamy, Sridhar; Benes, Cyril H.; Fisher, David E. (Public Library of Science, 2015)
      A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates in selected patients, but few patients achieve complete responses ...
    • The Role of Pigmentation and Oncogenic BRAF in Melanoma 

      Mitra, Devarati (2013-02-13)
      BRAF(V600E), the most commonly mutated oncogene in melanoma, is found in about half of patients. By hyperactivating the MAPK pathway, this mutation promotes cell growth and proliferation. Melanocytic BRAF(V600E) alone, ...
    • Tanning as a substance abuse 

      Robinson, Kathleen C; Fisher, David E (Taylor & Francis, 2014)
      While few people would deny the appeal of a day in the sun there are some who seem to take it too far. In recent years the concept of ‘tanning addiction’ has become popular and several studies have supported the notion of ...
    • Transcriptional Regulation of OCA2 and POMC by a cAMP-Dependent Mechanism and Implications in Skin Pigmentation 

      Veguilla, Rosa Angelica (2013-02-08)
      Skin Pigmentation represents the major natural protection against the deleterious effects of Ultraviolet light and involves a crosstalk between keratinocytes and melanocytes. Pigment synthesis or melanogenesis is initiated ...
    • UV signaling pathways within the skin 

      Chen, Hongxiang; Weng, Qing Yu; Fisher, David E. (2014)
      The effects of UVR on the skin include tanning, carcinogenesis, immunomodulation, and synthesis of vitamin D, among others. Melanocortin 1 receptor polymorphisms correlate with skin pigmentation, UV sensitivity, and skin ...
    • YY1 Regulates Melanocyte Development and Function by Cooperating with MITF 

      Li, Juying; Bell, Robert J. A.; Liu, Huifei; Love, Kevin T.; Larue, Lionel; Song, Jun S.; Tran, Thanh-Nga Trinh; Haq, Rizwan; Langer, Robert S.; Anderson, Daniel Griffith; Fisher, David Erich (Public Library of Science, 2012)
      Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed ...