Now showing items 1-2 of 2

    • BRCA1 and CtIP suppress long tract gene conversion between sister chromatids 

      Chandramouly, Gurushankar; Kwok, Amy; Huang, Bin; Willis, Nicholas A.; Xie, Anyong; Scully, Ralph (2013)
      BRCA1 controls early steps of the synthesis-dependent strand annealing (SDSA) pathway of homologous recombination, but has no known role following Rad51-mediated synapsis. Here we show that BRCA1 influences post-synaptic ...
    • Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks 

      Hartlerode, Andrea J.; Guan, Yinghua; Rajendran, Anbazhagan; Ura, Kiyoe; Schotta, Gunnar; Xie, Anyong; Shah, Jagesh V.; Scully, Ralph (Public Library of Science, 2012)
      Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several ...