Browsing by Author "Xavier, Ramnik J."

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    • Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy 

      Begun, Jakob; Lassen, Kara G.; Jijon, Humberto B.; Baxt, Leigh A.; Goel, Gautam; Heath, Robert J.; Ng, Aylwin; Tam, Jenny M.; Kuo, Szu-Yu; Villablanca, Eduardo J.; Fagbami, Lola; Oosting, Marije; Kumar, Vinod; Schenone, Monica; Carr, Steven A.; Joosten, Leo A.B.; Vyas, Jatin M.; Daly, Mark J.; Netea, Mihai G.; Brown, Gordon D.; Wijmenga, Cisca; Xavier, Ramnik J. (Cell Press, 2015)
      Summary The polymorphism ATG16L1 T300A, associated with increased risk of Crohn’s disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele ...