Now showing items 1-16 of 16

    • CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice 

      Felio, Kyrie; Nguyen, Hanh; Dascher, Christopher C.; Choi, Hak-Jong; Li, Sha; Zimmer, Michael I.; Colmone, Angela; Moody, D Branch; Brenner, Michael Barry; Wang, Chyung-Ru (Rockefeller University Press, 2009)
      Group 1 CD1 (CD1a, CD1b, and CD1c)–restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)–infected individuals. However, their role and dynamics ...
    • CD1b Tetramers Bind \(\alpha \beta\) T Cell Receptors to Identify a Mycobacterial Glycolipid-Reactive T Cell Repertoire in Humans 

      Cheng, Tan-Yun; Turner, Marie; Seshadri, Chetan; Schiefner, Andre; Kalathur, Ravi C.; Annand, John W.; de Jong, Annemieke; Shires, John; Wilson, Ian A.; Altman, John D.; Kasmar, Anne G.; Van Rhijn, Ildiko; Leon, Luis; Brenner, Michael Barry; Moody, D Branch (The Rockefeller University Press, 2011)
      Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. ...
    • CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids 

      Van Rhijn, Ildiko; De Jong, Annemieke; Vazquez, Jenny; Cheng, Tan-Yun; Barral, Duarte C.; León, Luis; Riese, Richard; Costello, Catherine E.; Porcelli, Steven A.; Briken, Volker; Young, David Stephenson; Young, David C.; Talekar, Rahul Subhash; Brenner, Michael Barry; Katz, Joel Thorp; Ruprecht, Ruth Margrit; O'Connor, Peter B.; Moody, D Branch (The Rockefeller University Press, 2009)
      The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ...
    • CD1c Bypasses Lysosomes to Present a Lipopeptide Antigen with 12 Amino Acids 

      De Jong, Annemieke; Vazquez, Jenny; Cheng, Tan-Yun; Barral, Duarte C.; León, Luis; Riese, Richard; Costello, Catherine E.; Porcelli, Steven A.; Briken, Volker; Van Rhijn, Ildiko; Young, David C.; Talekar, Rahul Subhash; Brenner, Michael Barry; Katz, Joel Thorp; Ruprecht, Ruth Margrit; O'Connor, Peter B.; Moody, D Branch (The Rockefeller University Press, 2009)
      The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ...
    • Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism 

      Noss, Erika H; Watts, Gerald FM; Zocco, Davide; Keller, Tracy L; Whitman, Malcolm; Blobel, Carl P; Lee, David M; Brenner, Michael B (BioMed Central, 2015)
      Introduction: Engagement of the homotypic cell-to-cell adhesion molecule cadherin-11 on rheumatoid arthritis (RA) synovial fibroblasts with a chimeric molecule containing the cadherin-11 extracellular binding domain ...
    • Flames, Splashes and Microdroplets: A Mathematical Approach to Three Fluid Dynamics Problems 

      Chemama, Michael Leopold (2015-01-13)
      Three different problems in fluid mechanics are presented in this thesis. The first one deals with the mechanism behind the extinction of a flame by an alternating electric field. A simple model for the interaction between ...
    • Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes 

      Narayan, Kavitha; Sylvia, Katelyn E.; Malhotra, Nidhi; Yin, Catherine C.; Martens, Gregory; Vallerskog, Therese; Kornfeld, Hardy; Xiong, Na; Cohen, Nadia Rachel; Brenner, Michael Barry; Berg, Leslie J.; Kang, Joonsoo (2012)
      γδ T cells function in the early phase of immune responses. Although innate γδ T cells have primarily been studied as one homogenous population, they can be functionally classified into effector subsets based on the ...
    • A Non-Parametric Perspective on the Analysis of Massive Networks 

      Costa, Thiago (2015-05-15)
      This dissertation develops an inferential framework for a highly non-parametric class of network models called graphons, which are the limit objects of converging sequences in the theory of dense graph limits. The theory, ...
    • Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway 

      Fineran, Paul; Lloyd-Evans, Emyr; Lack, Nathan A.; Platt, Nick; Davis, Lianne C.; Morgan, Anthony J.; Höglinger, Doris; Tatituri, Raju Venkata V.; Clark, Simon; Williams, Ian M.; Tynan, Patricia; Al Eisa, Nada; Nazarova, Evgeniya; Williams, Ann; Galione, Antony; Ory, Daniel S.; Besra, Gurdyal S.; Russell, David G.; Brenner, Michael B.; Sim, Edith; Platt, Frances M. (2016)
      Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term ...
    • Quantitative Methods for Analyzing Structure in Genomes, Self-Assembly, and Random Matrices 

      Huntley, Miriam (2016-05-20)
      This dissertation presents my graduate work analyzing biological structure. My research spans three different areas, which I discuss in turn. First I present my work studying how the genome folds. The three-dimensional ...
    • A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair 

      Encarnação, Marisa; Espada, Lília; Escrevente, Cristina; Mateus, Denisa; Ramalho, José; Michelet, Xavier; Santarino, Inês; Hsu, Victor W.; Brenner, Michael B.; Barral, Duarte C.; Vieira, Otília V. (The Rockefeller University Press, 2016)
      Lysosome exocytosis plays a major role in resealing plasma membrane (PM) disruptions. This process involves two sequential steps. First, lysosomes are recruited to the periphery of the cell and then fuse with the damaged ...
    • Regulatory iNKT cells lack PLZF expression and control Treg cell and macrophage homeostasis in adipose tissue 

      Lynch, Lydia; Michelet, Xavier; Zhang, Sai; Brennan, Patrick J.; Moseman, Ashley; Lester, Chantel; Besra, Gurdyal; Vomhof-Dekrey, Emilie E.; Tighe, Mike; Koay, Hui-Fern; Godfrey, Dale I.; Leadbetter, Elizabeth A.; Sant’Angelo, Derek B.; von Andrian, Ulrich; Brenner, Michael B. (2015)
      iNKT cells are CD1d-restricted lipid-sensing innate T cells that express the transcription factor PLZF. iNKT cells accumulate in adipose tissue, where they are anti-inflammatory, but the factors that contribute to their ...
    • Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells 

      Cohen, Nadia R.; Brennan, Patrick J.; Shay, Tal; Watts, Gerald F.; Brigl, Manfred; Kang, Joonsoo; Brenner, Michael B. (2013)
      Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled iNKT cell gene expression during ontogeny ...
    • Synthesis and Biological Activity of α-Galactosyl Ceramide KRN7000 and Galactosyl (α1→2) Galactosyl Ceramide 

      Veerapen, Natacha; Brigl, Manfred; Garg, Salil; Cerundolo, Vincenzo; Cox, Liam R.; Brenner, Michael Barry; Besra, Gurdyal S. (Elsevier Science Ltd, 2009)
      We herein report a faster and less cumbersome synthesis of the biologically attractive, α-galactosyl ceramide (α-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular ...
    • Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks 

      Malhotra, Deepali; Fletcher, Anne; Astarita, Jillian Leigh; Lukacs-Kornek, Veronika; Tayalia, Prakriti; Gonzalez, Santiago F.; Elpek, Kutlu G.; Chang, Sook Kyung; Knoblich, Konstantin; Hemler, Martin Edward; Brenner, Michael Barry; Carroll, Michael C.; Mooney, David J.; Turley, Shannon J. (Nature Publishing Group, 2012)
      Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of ...
    • Two-Dimensional Clusters of Colloidal Spheres: Ground States, Excited States, and Structural Rearrangements 

      Perry, Rebecca Wood; Holmes-Cerfon, Miranda C.; Brenner, Michael B; Manoharan, Vinothan N. (American Physical Society (APS), 2015)
      We study experimentally what is arguably the simplest yet nontrivial colloidal system: two-dimensional clusters of six spherical particles bound by depletion interactions. These clusters have multiple, degenerate ground ...