Now showing items 1-14 of 14

    • Abacavir Alters the Transcription of Inflammatory Cytokines in Virologically Suppressed, HIV-Infected Women 

      MacLeod, Iain James; Rowley, Christopher Francis; Lockman, Shahin; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; Mmalane, Mompati; Makhema, Joseph Moeketsi; Essex, Myron Elmer; Shapiro, Roger L. (International AIDS Society, 2012)
      Background: Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation. Methods: To evaluate the induction of inflammatory ...
    • An Augmented SMS Intervention to Improve Access to Antenatal CD4 Testing and ART Initiation in HIV-Infected Pregnant Women: A Cluster Randomized Trial 

      Dryden-Peterson, Scott; Bennett, Kara; Hughes, Michael D.; Veres, Adrian; John, Oaitse; Pradhananga, Rosina; Boyer, Matthew; Brown, Carolyn; Sakyi, Bright; van Widenfelt, Erik; Keapoletswe, Koona; Mine, Madisa; Moyo, Sikhulile; Asmelash, Aida; Siedner, Mark; Mmalane, Mompati; Shapiro, Roger L.; Lockman, Shahin (Public Library of Science, 2015)
      Background: Less than one-third of HIV-infected pregnant women eligible for combination antiretroviral therapy (ART) globally initiate treatment prior to delivery, with lack of access to timely CD4 results being a principal ...
    • Birth Weight for Gestational Age Norms for a Large Cohort of Infants Born to HIV-Negative Women in Botswana Compared with Norms for U.S.-Born Black Infants 

      Parekh, Natasha K; Binda, Kelebogile; Souda, Sajini; Essex, Max; Matthews, Lynn Turner; Ribaudo, Heather J.; Chen, Jennifer Yin-zu; Ogwu, Anthony; Makhema, Joseph Moeketsi; Lockman, Shahin; Shapiro, Roger L. (BioMed Central, 2011)
      Background: Standard values for birth weight by gestational age are not available for sub-Saharan Africa, but are needed to evaluate incidence and risk factors for intrauterine growth retardation in settings where HIV, ...
    • Co-Operative Additive Effects between HLA Alleles in Control of HIV-1 

      Matthews, Philippa C.; Listgarten, Jennifer; Carlson, Jonathan M.; Payne, Rebecca; Huang, Kuan-Hsiang Gary; Frater, John; Goedhals, Dominique; Steyn, Dewald; van Vuuren, Cloete; Paioni, Paolo; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger L.; Mncube, Zenele; Ndung'u, Thumbi; Walker, Bruce David; Heckerman, David; Goulder, Philip J. R. (Public Library of Science, 2012)
      Background: HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I ...
    • Cotrimoxazole Prophylaxis and Risk of Severe Anemia or Severe Neutropenia in HAART-Exposed, HIV-Uninfected Infants 

      Dryden-Peterson, Scott; Jayeoba, Oluwemimo; Hughes, Michael D.; Jibril, Haruna; McIntosh, Kenneth; Modise, Taolo A.; Asmelash, Aida; Powis, Kathleen M.; Essex, Max; Shapiro, Roger L.; Lockman, Shahin (Public Library of Science, 2013)
      Background: Prophylactic cotrimoxazole is recommended for infants born to HIV-infected mothers. However, cotrimoxazole may increase the risk of severe anemia or neutropenia. Methods: We compared the proportion of HIV-exposed ...
    • Dynamics and Frequency of Gag Transmitted Polymorphisms in Zambia 

      Claiborne, D; Kilembe, W; Ndung'u, T; Frater, J; Kaslow, R; Allen, S; Goepfert, P; Heckerman, D; Hunter, E; Schaefer, M; Carlson, J; Prince, J; Tang, J; Farmer, P; Shapiro, Roger L.; Goulder, P (BioMed Central, 2012)
    • High Prevalence of Hypertension and Placental Insufficiency, but No In Utero HIV Transmission, among Women on HAART with Stillbirths in Botswana 

      Souda, Sajini; Parekh, Natasha; Binda, Kelebogile; Kayembe, Mukendi; Svab, Petr; Babitseng, Orphinah; Jimbo, William; Creek, Tracy; Essex, Max; Shapiro, Roger L.; Lockman, Shahin; Powis, Kathleen Marie; Makhema, Joseph Moeketsi; Roberts, Drucilla Jane (Public Library of Science, 2012)
      Background: Increased stillbirth rates occur among HIV-infected women, but no studies have evaluated the pathological basis for this increase, or whether highly active antiretroviral therapy (HAART) influences the etiology ...
    • HIV-1 Subtype C-Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission 

      Baum, Marianna; Thior, Ibou; Asmelash, Aida; Campa, Adriana; van Widenfelt, Erik; Mine, Madisa; Moffat, Claire; Mmalane, Mompati; Gilbert, Peter; Novitsky, Vladimir A.; Wang, Rui; Bussmann, Hermann; Lockman, Shahin; Shapiro, Roger L.; Wester, Carolyn Negley; Wester, C William; Ogwu, Anthony; Musonda, Rosemary Mubanga; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Marlink, Richard George; Seage, George R.; De Gruttola, Victor Gerard; Essex, Myron Elmer (Public Library of Science, 2010)
      The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in Botswana, the median baseline plasma ...
    • HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults 

      Matthews, Philippa C.; Carlson, Jonathan M.; Beloukas, Apostolos; Malik, Amna; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger; Riddell, Lynn; Chen, Fabian; Luzzi, Graz; Jesuthasan, Gerald; Jeffery, Katie; Jojic, Nebojsa; Ndung'u, Thumbi; Carrington, Mary; Goulder, Philip J. R.; Geretti, Anna Maria; Klenerman, Paul (Oxford University Press, 2015)
      Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well ...
    • Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence 

      Payne, Rebecca; Muenchhoff, Maximilian; Mann, Jaclyn; Roberts, Hannah E.; Matthews, Philippa; Adland, Emily; Hempenstall, Allison; Huang, Kuan-Hsiang; Brockman, Mark; Brumme, Zabrina; Sinclair, Marc; Miura, Toshiyuki; Frater, John; Essex, Myron Elmer; Shapiro, Roger L.; Walker, Bruce David; Ndung’u, Thumbi; McLean, Angela R.; Carlson, Jonathan M.; Goulder, Philip J. R. (Proceedings of the National Academy of Sciences, 2014)
      It is widely believed that epidemics in new hosts diminish in virulence over time, with natural selection favoring pathogens that cause minimal disease. However, a tradeoff frequently exists between high virulence shortening ...
    • Nef-Specific CD8+ T Cell Responses Contribute to HIV-1 Immune Control 

      Adland, Emily; Carlson, Jonathan M.; Paioni, Paolo; Kløverpris, Henrik; Shapiro, Roger; Ogwu, Anthony; Riddell, Lynn; Luzzi, Graz; Chen, Fabian; Balachandran, Thambiah; Heckerman, David; Stryhn, Anette; Edwards, Anne; Ndung’u, Thumbi; Walker, Bruce D.; Buus, Søren; Goulder, Philip; Matthews, Philippa C. (Public Library of Science, 2013)
      Recent studies in the SIV-macaque model of HIV infection suggest that Nef-specific CD8+ T-cell responses may mediate highly effective immune control of viraemia. In HIV infection Nef recognition dominates in acute infection, ...
    • Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana 

      Matthews, Philippa C.; Beloukas, Apostolos; Malik, Amna; Carlson, Jonathan M.; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger; Riddell, Lynn; Chen, Fabian; Luzzi, Graz; Jaggernath, Manjeetha; Jesuthasan, Gerald; Jeffery, Katie; Ndung’u, Thumbi; Goulder, Philip J. R.; Geretti, Anna Maria; Klenerman, Paul (Public Library of Science, 2015)
      There is progressive concern about the evolving burden of morbidity and mortality caused by coinfection with HIV-1 and hepatitis B virus (HBV) in sub-Saharan Africa, but the epidemiology and impact of this problem are not ...
    • Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine 

      Lockman, Shahin; Shapiro, Roger L.; Smeaton, Laura Marie; Wester, Carolyn; Thior, Ibou; Stevens, Lisa; Chand, Fatima; Makhema, Joseph Moeketsi; Moffat, Claire; Asmelash, Aida; Ndase, Patrick; van Widenfelt, Peter Arimim Eri; Mazhani, Loeto; Novitsky, Vladimir A.; Lagakos, Stephen; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2007)
      BACKGROUND: A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants. METHODS: ...
    • Vitamin D Insufficiency in HIV-infected Pregnant Women Receiving Antiretroviral Therapy is Not Associated With Morbidity, Mortality or Growth Impairment in Their Uninfected Infants in Botswana 

      Powis, Kathleen Marie; Lockman, Shahin; Smeaton, Laura Marie; Hughes, Michael David; Fawzi, Wafaie W.; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; von Oettingen, Julia Elisabeth; Makhema, Joseph; Essex, Max; Shapiro, Roger L. (Ovid Technologies (Wolters Kluwer Health), 2014)
      Background Low maternal 25(OH)D (vitamin D) values have been associated with higher mortality and impaired growth among HIV-exposed uninfected (HEU) infants of antiretroviral (ART)-naïve women. These associations have ...