Browsing by Author "Srivastava, Amit"
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Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization
Gross, Jane; Bogaert, Debby; Finn, Adam; Bagrade, Linda; Zhang, Qibo; Kolls, Jay K.; Lundgren, Anna; Forte, Sophie; Lu, Ying-Jie; Srivastava, Amit Kumar; Thompson, Claudette M.; Harney, Kathleen; Anderson, Porter; Lipsitch, Marc; Malley, Richard (Public Library of Science, 2008)Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We ... -
Protection against Nasopharyngeal Colonization by Streptococcus pneumoniae Is Mediated by Antigen-Specific CD4+ T Cells
Trzciński, Krzysztof; Thompson, Claudette M.; Srivastava, Amit; Basset, Alan Emmanuel; Malley, Richard; Lipsitch, Marc (American Society for Microbiology, 2008)CD4(+) T-cell-dependent acquired immunity confers antibody-independent protection against pneumococcal colonization. Since this mechanism is poorly understood for extracellular bacteria, we assessed the antigen specificity ...