Now showing items 1-2 of 2

    • Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization 

      Gross, Jane; Bogaert, Debby; Finn, Adam; Bagrade, Linda; Zhang, Qibo; Kolls, Jay K.; Lundgren, Anna; Forte, Sophie; Lu, Ying-Jie; Srivastava, Amit Kumar; Thompson, Claudette M.; Harney, Kathleen; Anderson, Porter; Lipsitch, Marc; Malley, Richard (Public Library of Science, 2008)
      Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We ...
    • Protection against Nasopharyngeal Colonization by Streptococcus pneumoniae Is Mediated by Antigen-Specific CD4+ T Cells 

      Trzciński, Krzysztof; Thompson, Claudette M.; Srivastava, Amit; Basset, Alan Emmanuel; Malley, Richard; Lipsitch, Marc (American Society for Microbiology, 2008)
      CD4(+) T-cell-dependent acquired immunity confers antibody-independent protection against pneumococcal colonization. Since this mechanism is poorly understood for extracellular bacteria, we assessed the antigen specificity ...