Browsing by Author "Xia, Zongqi"

Now showing items 1-11 of 11

    • Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset 

      Bove, Riley; Chua, Alicia S.; Xia, Zongqi; Chibnik, Lori; De Jager, Philip L.; Chitnis, Tanuja (Wolters Kluwer, 2016)
      Objective: To examine the relationship between 2 markers of early multiple sclerosis (MS) onset, 1 genetic (HLA-DRB1*1501) and 1 experiential (early menarche), in 2 cohorts. Methods: We included 540 white women with MS or ...

    • Development of phenotype algorithms using electronic medical records and incorporating natural language processing 

      Liao, Katherine P; Cai, Tianxi; Savova, Guergana K; Murphy, Shawn N; Karlson, Elizabeth W; Ananthakrishnan, Ashwin N; Gainer, Vivian S; Shaw, Stanley Y; Xia, Zongqi; Szolovits, Peter; Churchill, Susanne; Kohane, Isaac (BMJ Publishing Group Ltd., 2015)
      Electronic medical records are emerging as a major source of data for clinical and translational research studies, although phenotypes of interest need to be accurately defined first. This article provides an overview of ...

    • Genes and Environment in Multiple Sclerosis Project: A Platform to Investigate Multiple Sclerosis Risk 

      Xia, Zongqi; White, Charles C.; Owen, Emily K.; Von Korff, Alina; Clarkson, Sarah R.; McCabe, Cristin; Cimpean, Maria; Winn, Phoebe A.; Hoesing, Ashley; Steele, Sonya U.; Cortese, Irene C. M.; Chitnis, Tanuja; Weiner, Howard; Reich, Daniel S.; Chibnik, Lori; De Jager, Philip (Wiley, 2016-02)
      The Genes and Environment in Multiple Sclerosis (GEMS) project establishes a platform to investigate the events leading to MS in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using ...

    • High-Throughput Phenotyping With Electronic Medical Record Data Using a Common Semi-Supervised Approach (PheCAP) 

      Zhang, Yichi; Cai, Tianrun; Yu, Sheng; Cho, Kelly; Hong, Chuan; Sun, Jiehuan; Huang, Jie; Xia, Zongqi; Castro, Victor; Gagnon, David; Savova, Guergana; Churchill, Susanne; Gaziano, John; Kohane, Isaac; Cai, Tianxi; Ho, Yuk-Lam; Ananthakrishnan, Ashwin; Shaw, Stanley; Gainer, Vivian; Link, Nicholas; Honerlaw, Jacqueline; Huong, Sicong; Karlson, Elizabeth; Plenge, Robert; Szolovits, Peter; O'Donnell, Christopher; Murphy, Shawn; Liao, Katherine (Springer Science and Business Media LLC, 2019-11-20)
      Phenotypes are the foundation for clinical and genetic studies of disease risk and outcomes. The growth of biobanks linked to electronic medical record (EMR) data has both facilitated and increased the demand for efficient, ...

    • Hypertrophic Pachymeningitis and Cerebral Venous Sinus Thrombosis in Inflammatory Bowel Disease 

      Xia, Zongqi; Chen-Plotkin, Alice; Schmahmann, Jeremy (Elsevier BV, 2010-11)
      Hypertrophic pachymeningitis is rarely observed in inflammatory bowel disease. We report a woman with ulcerative colitis whose biopsy-confirmed hypertrophic pachymeningitis was complicated by cerebral venous sinus thrombosis ...

    • Improving Case Definition of Crohnʼs Disease and Ulcerative Colitis in Electronic Medical Records Using Natural Language Processing 

      Ananthakrishnan, Ashwin; Cai, Tianxi; Savova, Guergana; Cheng, Su-Chun; Chen, Pei; Guzman, Raul; Gainer, Vivian S.; Murphy, Shawn; Szolovits, Peter; Xia, Zongqi; Shaw, Stanley; Churchill, Susanne; Karlson, Elizabeth; Kohane, Isaac; Plenge, Robert M.; Liao, Katherine (Oxford University Press (OUP), 2013-06)
      Introduction Prior studies identifying patients with inflammatory bowel disease (IBD) utilizing administrative codes have yielded inconsistent results. Our objective was to develop a robust electronic medical record (EMR) ...

    • Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts 

      Liao, Katherine P.; Ananthakrishnan, Ashwin N.; Kumar, Vishesh; Xia, Zongqi; Cagan, Andrew; Gainer, Vivian S.; Goryachev, Sergey; Chen, Pei; Savova, Guergana K.; Agniel, Denis; Churchill, Susanne; Lee, Jaeyoung; Murphy, Shawn N.; Plenge, Robert M.; Szolovits, Peter; Kohane, Isaac; Shaw, Stanley Y.; Karlson, Elizabeth W.; Cai, Tianxi (Public Library of Science, 2015)
      Background: Typically, algorithms to classify phenotypes using electronic medical record (EMR) data were developed to perform well in a specific patient population. There is increasing interest in analyses which can allow ...

    • Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records 

      Xia, Zongqi; Secor, Elizabeth; Chibnik, Lori B.; Bove, Riley M.; Cheng, Suchun; Chitnis, Tanuja; Cagan, Andrew; Gainer, Vivian S.; Chen, Pei J.; Liao, Katherine P.; Shaw, Stanley Y.; Ananthakrishnan, Ashwin N.; Szolovits, Peter; Weiner, Howard L.; Karlson, Elizabeth W.; Murphy, Shawn N.; Savova, Guergana K.; Cai, Tianxi; Churchill, Susanne E.; Plenge, Robert M.; Kohane, Isaac S.; De Jager, Philip L. (Public Library of Science, 2013)
      Objective: To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we need to accurately identify patients and extract ...

    • Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease 

      Ananthakrishnan, Ashwin; Cagan, Andrew; Gainer, Vivian S.; Cai, Tianxi; Cheng, Su-Chun; Savova, Guergana; Chen, Pei; Szolovits, Peter; Xia, Zongqi; De Jager, Philip; Shaw, Stanley; Churchill, Susanne; Karlson, Elizabeth; Kohane, Isaac; Plenge, Robert; Murphy, Shawn; Liao, Katherine (Oxford University Press (OUP), 2013-08-01)
      Introduction Vitamin D may have an immunological role in Crohn’s disease (CD) and ulcerative colitis (UC). Retrospective studies suggested a weak association between vitamin D status and disease activity but have significant ...

    • Paraneoplastic limbic encephalitis presenting as a neurological emergency: a case report 

      Xia, Zongqi; Mehta, Brijesh P; Ropper, Allan; Kesari, Santosh (Springer Science and Business Media LLC, 2010-03-24)
      Introduction Paraneoplastic limbic encephalitis remains a challenging clinical diagnosis with poor outcome if it is not recognized and treated early in the course of the disease. Case Presentation A 65-year-old ...

    • A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis 

      Xia, Zongqi; Chibnik, Lori; Glanz, Bonnie; Liguori, Maria; Shulman, Joshua M.; Tran, Dong; Khoury, Samia; Chitnis, Tanuja; Holyoak, Todd; Weiner, Howard; Guttmann, Charles; De Jager, Philip L. (Public Library of Science (PLoS), 2010-11-30)
      Background Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset ...