Now showing items 1-3 of 3

    • Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks 

      Hartlerode, Andrea J.; Guan, Yinghua; Rajendran, Anbazhagan; Ura, Kiyoe; Schotta, Gunnar; Xie, Anyong; Shah, Jagesh V.; Scully, Ralph (Public Library of Science, 2012)
      Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several ...
    • LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair 

      Liu, Xue-Song; Chandramouly, Gurushankar; Rass, Emilie; Guan, Yinghua; Wang, Guocan; Hobbs, Robin M.; Rajendran, Anbazhagan; Xie, Anyong; Shah, Jagesh V.; Davis, Anthony J.; Scully, Ralph; Lunardi, Andrea; Pandolfi, Pier Paolo (Nature Pub. Group, 2015)
      Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krüppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis. Here we demonstrate an unexpected ...
    • PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways 

      Beck, Carole; Boehler, Christian; Guirouilh Barbat, Josée; Bonnet, Marie-Elise; Illuzzi, Giuditta; Ronde, Philippe; Gauthier, Laurent R.; Magroun, Najat; Rajendran, Anbazhagan; Lopez, Bernard S.; Scully, Ralph; Boussin, François D.; Schreiber, Valérie; Dantzer, Françoise (Oxford University Press, 2014)
      The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) and classical or alternative nonhomologous end ...