Browsing by Author "Burleigh, Barbara"
Now showing items 1-4 of 4
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Cytokine-Dependent and -Independent Gene Expression Changes and Cell Cycle Block revealed in Trypanosoma cruzi-infected Host Cells by Comparative mRNA Profiling
Costales, Jaime A; Daily, Johanna P; Burleigh, Barbara (BioMed Central, 2009)Background: The requirements for growth and survival of the intracellular pathogen Trypanosoma cruzi within mammalian host cells are poorly understood. Transcriptional profiling of the host cell response to infection serves ... -
Selection at Work in Plasmodium Falciparum: Lessons From the Expanded Acyl CoA Synthetase Gene Family and in Vitro Artemisinin Resistance.
Demas, Allison Ross (2016-05-18)Approximately one third of the world’s population is at risk of contracting malaria. The World Health Organization estimates there were over 200 million news cases of malaria in 2015, resulting in nearly 500,000 deaths ... -
Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
Li, Yuan; Shah-Simpson, Sheena; Okrah, Kwame; Belew, A. Trey; Choi, Jungmin; Caradonna, Kacey L.; Padmanabhan, Prasad; Ndegwa, David M.; Temanni, M. Ramzi; Corrada Bravo, Héctor; El-Sayed, Najib M.; Burleigh, Barbara A. (Public Library of Science, 2016)Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite, Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global insights into the T. cruzi infective ... -
Trypanosome Lytic Factor, an Antimicrobial High-Density Lipoprotein, Ameliorates Leishmania Infection
Samanovic, Marie; Molina-Portela, Maria Pilar; Chessler, Anne-Danielle C.; Burleigh, Barbara; Raper, Jayne (Public Library of Science, 2009)Innate immunity is the first line of defense against invading microorganisms. Trypanosome Lytic Factor (TLF) is a minor sub-fraction of human high-density lipoprotein that provides innate immunity by completely protecting ...