Browsing by Author "Bilge, Aykut"

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A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia

Lobo, Kimberly; Donado, Carolina; Cornelissen, Laura Louise; Kim, Joseph; Ortiz, Rebeca; Peake, Roy; Kellogg, Mark David; Alexander, Mark Edward; Zurakowski, David; Kurgansky, Katherine E.; Peyton, James Matthew; Bilge, Aykut; Boretsky, Karen Rach; McCann, Mary Ellen; Berde, Charles Benjamin; Cravero, Joseph Peter (Ovid Technologies (Wolters Kluwer Health), 2015)

BACKGROUND: Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, ...