Browsing by Author "Khanna, Arjun"
Now showing items 1-8 of 8
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Electroencephalographic Microstate Correlates of Fluid Intelligence
Khanna, Arjun R. (2016-05-17)The neurobiological correlates of human fluid intelligence (Gf) remain elusive. Converging lines of evidence suggest a pivotal role for the efficiency and connectivity of anatomically-defined brain networks, but little is ... -
Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain
Zhang, Jinwei; Gao, Geng; Begum, Gulnaz; Wang, Jinhua; Khanna, Arjun R.; Shmukler, Boris E.; Daubner, Gerrit M.; de los Heros, Paola; Davies, Paul; Varghese, Joby; Bhuiyan, Mohammad Iqbal H.; Duan, Jinjing; Zhang, Jin; Duran, Daniel; Alper, Seth L.; Sun, Dandan; Elledge, Stephen J.; Alessi, Dario R.; Kahle, Kristopher T. (Nature Publishing Group, 2016)Cell volume homeostasis requires the dynamically regulated transport of ions across the plasmalemma. While the ensemble of ion transport proteins involved in cell volume regulation is well established, the molecular ... -
Glioblastoma Mimicking an Arteriovenous Malformation
Khanna, Arjun; Venteicher, Andrew S.; Walcott, Brian P.; Kahle, Kristopher T.; Mordes, Daniel A.; William, Christopher M.; Ghogawala, Zoher; Ogilvy, Christopher S. (Frontiers Media S.A., 2013)Abnormal cerebral vasculature can be a manifestation of a vascular malformation or a neoplastic process. We report the case of a patient with angiography-negative subarachnoid hemorrhage (SAH) who re-presented 3 years later ... -
Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl− Transport
Khanna, Arjun; Walcott, Brian Patrick; Kahle, Kristopher T. (Frontiers Media S.A., 2013)Neonatal intensive care has advanced rapidly in the last 40 years, with dramatic decreases in mortality and morbidity; however, for neonatal seizures, neither therapies nor outcomes have changed significantly. Basic and ... -
Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis
Adragna, Norma C.; Ravilla, Nagendra B.; Lauf, Peter K.; Begum, Gulnaz; Khanna, Arjun R.; Sun, Dandan; Kahle, Kristopher T. (Frontiers Media S.A., 2015)The defense of cell volume against excessive shrinkage or swelling is a requirement for cell function and organismal survival. Cell swelling triggers a coordinated homeostatic response termed regulatory volume decrease ... -
Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia
Merner, Nancy D.; Chandler, Madison R.; Bourassa, Cynthia; Liang, Bo; Khanna, Arjun R.; Dion, Patrick; Rouleau, Guy A.; Kahle, Kristopher T. (Frontiers Media S.A., 2015)Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on ... -
Reliability of Resting-State Microstate Features in Electroencephalography
Khanna, Arjun; Pascual-Leone, Alvaro; Farzan, Faranak (Public Library of Science, 2014)Background: Electroencephalographic (EEG) microstate analysis is a method of identifying quasi-stable functional brain states (“microstates”) that are altered in a number of neuropsychiatric disorders, suggesting their ... -
Time interval to surgery and outcomes following the surgical treatment of acute traumatic subdural hematoma
Walcott, Brian; Khanna, Arjun Ramesh; Kwon, Churl-Su; Phillips, H. Westley; Nahed, Brian Vala; Coumans, Jean-Valery C E (Elsevier BV, 2014)Although the pre-surgical management of patients with acute traumatic subdural hematoma prioritizes rapid transport to the operating room, there is conflicting evidence regarding the importance of time interval from injury ...