Now showing items 1-3 of 3

    • The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD 

      Suzuki, Naoki; Maroof, Asif; Merkle, Florian T; Koszka, Kathryn; Intoh, Atsushi; Armstrong, Ian; Moccia, Rob; Davis-Dusenbery, Brandi N; Eggan, Kevin (2014)
      Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was ...
    • Nanog-Independent Reprogramming to iPSCs with Canonical Factors 

      Carter, Ava C.; Davis-Dusenbery, Brandi N.; Koszka, Kathryn; Ichida, Justin K.; Eggan, Kevin (Elsevier, 2014)
      Summary It has been suggested that the transcription factor Nanog is essential for the establishment of pluripotency during the derivation of embryonic stem cells and induced pluripotent stem cells (iPSCs). However, ...
    • A small molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog 

      Ichida, Justin K.; Blanchard, Joel; Lam, Kelvin; Son, Esther Y.; Chung, Julia E.; Egli, Dieter; Loh, Kyle M.; Carter, Ava C.; Di Giorgio, Francesco P.; Koszka, Kathryn E; Huangfu, Danwei; Akutsu, Hidenori; Liu, David Ruchien; Rubin, Lee; Eggan, Kevin Carl (Elsevier BV, 2009)
      The combined activity of three transcription factors can reprogram adult cells into induced pluripotent stem (iPS) cells. However, the transgenic methods used to deliver reprogramming factors have raised concerns regarding ...