Browsing by Author "Krishnan, Ramaswamy"

Now showing items 1-9 of 9

    • Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice 

      Hiorns, Jonathan E.; Bidan, Cécile M.; Jensen, Oliver E.; Gosens, Reinoud; Kistemaker, Loes E. M.; Fredberg, Jeffrey J.; Butler, Jim P.; Krishnan, Ramaswamy; Brook, Bindi S. (Frontiers Media S.A., 2016)
      The precision-cut lung slice (PCLS) is a powerful tool for studying airway reactivity, but biomechanical measurements to date have largely focused on changes in airway caliber. Here we describe an image processing tool ...

    • Cell Elasticity Determines Macrophage Function 

      Patel, Naimish R.; Bole, Medhavi; Chen, Cheng; Hardin, Charles Corey; Kho, Alvin Thong-Juak; Mih, Justin; Deng, Linhong; Butler, James Preston; Tschumperlin, Daniel J.; Fredberg, Jeffrey J.; Krishnan, Ramaswamy; Koziel, Henryk (Public Library of Science, 2012)
      Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central ...

    • Fluidization and Resolidification of the Human Bladder Smooth Muscle Cell in Response to Transient Stretch 

      Rajendran, Kavitha; Deng, Linhong; Sokolov, Igor; Chen, Cheng; Krishnan, Ramaswamy; Zhou, Enhua; Ramachandran, Aruna; Tambe, Dhananjay T; Adam, Rosalyn Mare; Fredberg, Jeffrey J. (Public Library of Science, 2010)
      Background: Cells resident in certain hollow organs are subjected routinely to large transient stretches, including every adherent cell resident in lungs, heart, great vessels, gut, and bladder. We have shown recently that ...

    • Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing 

      Feng, Di; Steinke, Julia M.; Krishnan, Ramaswamy; Birrane, Gabriel; Pollak, Martin R. (Public Library of Science, 2016)
      Genetic testing in the clinic and research lab is becoming more routinely used to identify rare genetic variants. However, attributing these rare variants as the cause of disease in an individual patient remains challenging. ...

    • Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly 

      Tojkander, Sari; Gateva, Gergana; Husain, Amjad; Krishnan, Ramaswamy; Lappalainen, Pekka (eLife Sciences Publications, Ltd, 2015)
      Adhesion and morphogenesis of many non-muscle cells are guided by contractile actomyosin bundles called ventral stress fibers. While it is well established that stress fibers are mechanosensitive structures, physical ...

    • JunB Mediates Basal- and TGFβ1-Induced Smooth Muscle Cell Contractility 

      Ramachandran, Aruna; Gangopadhyay, Samudra Saurabh; Krishnan, Ramaswamy; Ranpura, Sandeep A.; Rajendran, Kavitha; Ram-Mohan, Sumati; Mulone, Michelle; Gong, Edward M.; Adam, Rosalyn Mare (Public Library of Science, 2013)
      Smooth muscle contraction is a dynamic process driven by acto-myosin interactions that are controlled by multiple regulatory proteins. Our studies have shown that members of the AP-1 transcription factor family control ...

    • Propulsion and navigation within the advancing monolayer sheet 

      Kim, Jae Hun; Serra-Picamal, Xavier; Tambe, Dhananjay; Zhou, Enhua; Park, Chan Young Young; Sadati, Monirosadat; Park, Jin-Ah; Krishnan, Ramaswamy; Gweon, Bomi; Millet, Emil; Butler, James P.; Trepat, Xavier; Fredberg, Jeffrey J. (Springer Nature, 2013)
      As a wound heals, or a body plan forms, or a tumour invades, observed cellular motions within the advancing cell swarm are thought to stem from yet to be observed physical stresses that act in some direct and causal ...

    • Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes 

      Morley, Samantha; You, Sungyong; Pollan, Sara; Choi, Jiyoung; Zhou, Bo; Hager, Martin H.; Steadman, Kenneth; Spinelli, Cristiana; Rajendran, Kavitha; Gertych, Arkadiusz; Kim, Jayoung; Adam, Rosalyn M.; Yang, Wei; Krishnan, Ramaswamy; Knudsen, Beatrice S.; Di Vizio, Dolores; Freeman, Michael R. (Nature Publishing Group, 2015)
      Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate ...

    • Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness 

      Heintzmann, Rainer; Krishnan, Ramaswamy; Park, Chan Young Young; Lin, Yu-Chun; Mead, Jere; Jaspers, Richard T.; Trepat, Xavier; Lenormand, Guillaume; Tambe, Dhananjay T; Smolensky, Alexander; Knoll, Andrew Herbert; Butler, James Preston; Fredberg, Jeffrey J. (Public Library of Science, 2009)
      Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences large periodic stretches. As ...